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5-Iodo-indirubin-3'-monoxime

Catalog No.GC35162

La 5-iodo-indirubine-3'-monoxime est un puissant inhibiteur de GSK-3β, CDK5/P25 et CDK1/cycline B, en compétition avec l'ATP pour la liaison au site catalytique de la kinase, avec des IC50 de 9, 20 et 25 nM, respectivement.

Products are for research use only. Not for human use. We do not sell to patients.

5-Iodo-indirubin-3'-monoxime Chemical Structure

Cas No.: 331467-03-9

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively[1]. GSK-3β|9 nM (IC50)|Cdk5/p25|20 nM (IC50)|Cdk1/cyclin B|25 nM (IC50)

[1]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors• J Biol Chem. 2001 Jan 5;276(1):251-60.

Chemical Properties

Cas No. 331467-03-9 SDF
Canonical SMILES O/N=C(C1=CC=CC=C1N2)/C2=C3C(NC4=C/3C=C(I)C=C4)=O
Formula C16H10IN3O2 M.Wt 403.17
Solubility DMSO: 67.5 mg/mL (167.42 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.4803 mL 12.4017 mL 24.8034 mL
5 mM 0.4961 mL 2.4803 mL 4.9607 mL
10 mM 0.248 mL 1.2402 mL 2.4803 mL
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Review for 5-Iodo-indirubin-3'-monoxime

Average Rating: 5 ★★★★★ (Based on Reviews and 12 reference(s) in Google Scholar.)

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