Accueil>>Signaling Pathways>> Ubiquitination/ Proteasome>> Autophagy>>AGN 195183

AGN 195183 (Synonyms: IRX-5183; VTP-195183; NRX-195183)

Catalog No.GC35265

AGN 195183 (IRX-5183) est un agoniste puissant et sélectif de RARα (Kd \u003d 3 nM) avec une sélectivité de liaison améliorée par rapport à AGN 193836. AGN 195183 n'a aucune activité sur RARβ/γ.

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AGN 195183 Chemical Structure

Cas No.: 367273-07-2

Taille Prix Stock Qté
10mM (in 1mL DMSO)
260,00 $US
En stock
2mg
180,00 $US
En stock
5mg
270,00 $US
En stock
10mg
386,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

AGN 195183 is a potent and selective agonist of RARα(Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RARβ/γ.IC50 value: 3 nM (Kd); 200 nM (EC80, RAR Trans.)Target: RARα agonistCompound 4(AGN-195183) inhibited the growth of breast cancer cell lines, and was inactive in an in vivo model of topical irritation.Compound 4 and ATRA inhibit growth of the human breast cancer cell lines, T-47D and SK-BR-3, compound 4 does not cause the topical irritation induced by the RARa-selective retinoid, Am-580. Compound 4 (AGN 195183) is currently in Phase I/IIA clinical trials in cancer patients.

[1]. Beard RL, et al. Synthesis and biological activity of retinoic acid receptor-alpha specific amides. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3145-8.

Chemical Properties

Cas No. 367273-07-2 SDF
Synonymes IRX-5183; VTP-195183; NRX-195183
Canonical SMILES O=C(O)C1=C(F)C=C(NC(C2=C(O)C(Cl)=C3C(C)(C)CCC(C)(C)C3=C2)=O)C=C1F
Formula C22H22ClF2NO4 M.Wt 437.86
Solubility DMSO: ≥ 62 mg/mL (141.60 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.2838 mL 11.4192 mL 22.8384 mL
5 mM 0.4568 mL 2.2838 mL 4.5677 mL
10 mM 0.2284 mL 1.1419 mL 2.2838 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 22 reference(s) in Google Scholar.)

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