ALK-IN-6 |
| Catalog No.GC35290 |
ALK-IN-6 (composé 11) est un inhibiteur biodisponible par voie orale de la kinase du lymphome anaplasique (ALK), avec des valeurs IC50 de 71 nM, 18,72 nM et 36,81 nM pour ALK sauvage, ALK F1196M et ALK F1174L, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2055821-33-3
Sample solution is provided at 25 µL, 10mM.
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ALK-IN-6 (compound 11) is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK), with IC50 values of 71 nM, 18.72 nM and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L, respectively[1]. IC50: 71 nM (ALK wild), 18.72 nM (ALK F1196M), 36.81 nM (ALK F1174L)[1].
[1]. Das D, et al. Design, synthesis of orally bioavailable novel anaplastic lymphoma kinase (ALK) inhibitor diphenylaminopyrimidine analogs and efficacy study on NCI-H2228 xenografts mice model. Bioorg Med Chem Lett. 2019 Jun 15;29(12):1514-1517.
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