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DK419

Catalog No.GC35873

DK419 est un inhibiteur de signalisation Wnt/β-caténine puissant et actif par voie orale, avec une IC50 de 0,19 μM. DK419 réduit les niveaux de protéines d'Axin2, de β-caténine, de c-Myc, de Cycline D1 et de Survivine et induit la production de pAMPK.

Products are for research use only. Not for human use. We do not sell to patients.

DK419 Chemical Structure

Cas No.: 2102672-22-8

Taille Prix Stock Qté
10mM (in 1mL DMSO)
347,00 $US
En stock
1mg
120,00 $US
En stock
5mg
315,00 $US
En stock
10mg
495,00 $US
En stock
50mg
1 485,00 $US
En stock
100mg
2 025,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK[1]. Wnt/β-catenin[1]

[1]. Wang J, et al. Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442.

Chemical Properties

Cas No. 2102672-22-8 SDF
Canonical SMILES O=C(C1=C2C(N=C(C(F)(F)F)N2)=CC(Cl)=C1)NC3=CC=C(C(F)(F)F)C=C3
Formula C16H8ClF6N3O M.Wt 407.7
Solubility DMSO: 83.33 mg/mL (204.39 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.4528 mL 12.2639 mL 24.5278 mL
5 mM 0.4906 mL 2.4528 mL 4.9056 mL
10 mM 0.2453 mL 1.2264 mL 2.4528 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for DK419

Average Rating: 5 ★★★★★ (Based on Reviews and 6 reference(s) in Google Scholar.)

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