Foxy-5 |
| Catalog No.GC36073 |
Foxy-5, un agoniste de WNT5A, est un peptide mimant de WNT5A qui est un membre non canonique de la famille Wnt. Foxy-5 déclenche la signalisation du calcium libre cytosolique sans affecter l'activation de la β-caténine et altère la migration et l'invasion des cellules cancéreuses épithéliales. Foxy-5 réduit efficacement la propagation métastatique des cellules cancéreuses de la prostate WNT5A-low dans un modèle de souris orthotopique.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 881188-51-8
Sample solution is provided at 25 µL, 10mM.
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Foxy-5 is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 is a WNT5A agonist and effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model[1][2]. WNT5A[1]
Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model[1].Foxy-5 reduces the number of colonic cancer stem cells in a xenograft mouse model of human colonic cancer[2].
[1]. Canesin G, et al. Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One. 2017 Sep 8;12(9):e0184418. [2]. Osman J, et al. The WNT5A Agonist Foxy5 Reduces the Number of Colonic Cancer Stem Cells in a Xenograft Mouse Model of Human Colonic Cancer. Anticancer Res. 2019 Apr;39(4):1719-1728.
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