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K-Ras G12C-IN-2

Catalog No.GC36399

K-Ras G12C-IN-2 est un inhibiteur covalent irréversible de K-Ras G12C.

Products are for research use only. Not for human use. We do not sell to patients.

K-Ras G12C-IN-2 Chemical Structure

Cas No.: 1629267-75-9

Taille Prix Stock Qté
1mg
139,00 $US
En stock
5mg
324,00 $US
En stock
10mg
464,00 $US
En stock
50mg
1 947,00 $US
En stock
100mg
3 337,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

K-Ras G12C-IN-2 is an irreversible covalent K-Ras G12C inhibitor. KRas G12C

K-Ras G12C-IN-2 is a covalent kras g12c inhibitor extracted from patent WO2014152588A1, compound V-35[1].

[1]. Pingda Ren, et al. Covalent inhibitors of kras g12c. WO2014152588A1

Chemical Properties

Cas No. 1629267-75-9 SDF
Canonical SMILES ClC1=C(C2CC2)C=C(NCC(N3CCN(C4CN(C(C=C)=O)C4)CC3)=O)C(O)=C1
Formula C21H27ClN4O3 M.Wt 418.92
Solubility DMSO: ≥ 22 mg/mL (52.52 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.3871 mL 11.9355 mL 23.8709 mL
5 mM 0.4774 mL 2.3871 mL 4.7742 mL
10 mM 0.2387 mL 1.1935 mL 2.3871 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for K-Ras G12C-IN-2

Average Rating: 5 ★★★★★ (Based on Reviews and 37 reference(s) in Google Scholar.)

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