β-Amyrin (Synonyms: (+)-β-Amyrin, NSC 527971, Olean-12-en3β-ol)

β-Amyrin is a natural pentacyclic triterpenoid commonly found in plants. It is a member of the oleanane group of secondary metabolites biosynthesized from squalene in the triterpenoid pathway. β-Amyrin inhibits collagen-induced platelet aggregation (IC50 = 10.5 μM), inhibits acetylcholinesterase (IC50 = 165 μM), and has antifungal and hepatoprotective effects.1,2,3,4 Extracts of certain plants, used in herbal medicine to treat inflammation, have been shown to contain β-amyrin, suggesting that this compound contributes to anti-inflammatory actions.5

References
1. Ching, J., Chua, T.K., Chin, L.C., et al. Beta-amyrin from Ardisia elliptica Thunb. is more potent than aspirin in inhibiting collagen-induced platelet aggregation. Indian J. Exp. Biol. 48(3), 275-279 (2010).
2. Jabeen, K., Javid, A., Ahmad, E., et al. Antifungal compounds from Melia azedarach leaves for management of Ascochyta rabiei, the cause of chickpea blight. Nat. Prod. Res. 25(3), 264-276 (2011).
3. Oliveira, F.A., Chaves, M.H., Almeida, F.R., et al. Protective effect of alpha- and beta-amyrin, a triterpene mixture from Protium heptaphyllum (Aubl.) March. trunk wood resin, against acetaminophen-induced liver injury in mice. J. Ethnopharmacol. 98(1-2), 103-108 (2005).
4. Park, S.J., Ahn, Y.J., Oh, S.R., et al. Amyrin attenuates scopolamine-induced cognitive impairment in mice. Biol. Pharm. Bull. 37(7), 1207-1213 (2014).
5. Ferraz-Filha, Z.S., de Paula Michel AraÚjo, M.C., Ferrari, F.C., et al. Tabebuia roseoalba: In vivo hypouricemic and anti-inflammatory effects of its ethanolic extract and constituents. Planta Med. 82(16), 1395-1402 (2016).