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GOAT-IN-1

Catalog No.GC31080

GOAT-IN-1 est un inhibiteur de la ghréline O-acyltransférase (GOAT), qui pourrait être utile pour la prophylaxie ou le traitement de l'obésité, du diabète, de l'hyperlipidémie, de la stéatose métabolique, du foie gras non alcoolique, de la stéatohépatite, de la sarcopénie, du contrÔle de l'appétit, de l'alcool/ dépendance aux narcotiques, maladie d'Alzheimer, maladie de Parkinson, démence cérébrovasculaire, apoplexie cérébrale, infarctus cérébral, maladie cardiaque, certains types de tumeurs.

Products are for research use only. Not for human use. We do not sell to patients.

GOAT-IN-1 Chemical Structure

Cas No.: 1452473-54-9

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of obesity, diabetes, hyperlipidemia, metabolic, non-alcoholic fatty liver, steatohepatitis, sarcopenia, appetite control, alcohol/narcotic dependence, Alzheimer's disease, Parkinson's disease, cerebrovascular dementia, cerebral apoplexy, cerebral infarction, cardic disease, some kind of tumors.

The inhibitory activity of GOAT-IN-1 (Example 16) for human GOAT is 101% with the concentration of 10 μM[1].

[1]. WO 2013125732.

Chemical Properties

Cas No. 1452473-54-9 SDF
Canonical SMILES CC1=NC(C(F)(F)F)=CC=C1COC2=CC(SC=C3CC(O)=O)=C3C(Cl)=C2
Formula C18H13ClF3NO3S M.Wt 415.81
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.4049 mL 12.0247 mL 24.0494 mL
5 mM 0.481 mL 2.4049 mL 4.8099 mL
10 mM 0.2405 mL 1.2025 mL 2.4049 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 29 reference(s) in Google Scholar.)

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