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(-)-L-threo-PDMP (hydrochloride)

Catalog No.GC45250

(-)-L-threo-PDMP is an enhancer of ganglioside biosynthesis.

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(-)-L-threo-PDMP (hydrochloride) Chemical Structure

Cas No.: 161491-04-9

Taille Prix Stock Qté
1mg
91,00 $US
En stock
5mg
385,00 $US
En stock
10mg
682,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(-)-L-threo-PDMP is an enhancer of ganglioside biosynthesis. The (-)-L-threo-PDMP (1S,2S) isomer is the active stimulatory component of DL-threo-PDMP in contrast to (+)-D-threo-PDMP , which is an inhibitor of glucosylceramide synthetase. (-)-L-threo-PDMP upregulates GM3, GD3, and GQ1b synthase levels, which are glycosyltransferases involved in ganglioside biosynthesis, and increases ganglioside levels in cells. It increases neurite outgrowth and synapse formation in vitro and improves retention of a long-term memory learned prior to forebrain ischemia in rats when administered following ischemia at a dose of 40 mg/kg per day.

Chemical Properties

Cas No. 161491-04-9 SDF
Canonical SMILES CCCCCCCCCC(N[C@H]([C@@H](O)C1=CC=CC=C1)CN2CCOCC2)=O.Cl
Formula C23H38N2O3•HCl M.Wt 427
Solubility Ethanol: Soluble,Methanol: Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.3419 mL 11.7096 mL 23.4192 mL
5 mM 0.4684 mL 2.3419 mL 4.6838 mL
10 mM 0.2342 mL 1.171 mL 2.3419 mL
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Review for (-)-L-threo-PDMP (hydrochloride)

Average Rating: 5 ★★★★★ (Based on Reviews and 11 reference(s) in Google Scholar.)

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