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Milbemycin D

Catalog No.GC18668

Milbemycin D is an insecticidal and anthelmintic antibiotic originally isolated from S.

Products are for research use only. Not for human use. We do not sell to patients.

Milbemycin D Chemical Structure

Cas No.: 77855-81-3

Taille Prix Stock Qté
1mg
394,00 $US
En stock
5mg
1 478,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Milbemycin D is an insecticidal and anthelmintic antibiotic originally isolated from S. hygroscopicus. It is toxic to third instar gypsy moth larvae with an LD50 value of 0.119 ug/g but not to sixth instar larvae. Milbemycin D eradicates A. caninum and is effective against T. canis in dogs when administered at doses of 0.05 and 0.1 mg/kg. It prevents D. immitis infection in dogs, but is not effective against T. vulpis or D. caninum. Milbemycin D also activates glutamate- (EC50 = 89 nM) and GABA-gated chloride channels.

Chemical Properties

Cas No. 77855-81-3 SDF
Chemical Name 5-O-demethyl-28-deoxy-6R,28-epoxy-25R-(1-methylethyl)-milbemycin B
Canonical SMILES O=C([C@@]1([H])[C@@]2(O)[C@@]3([H])[C@H](O)C(C)=C1)O[C@@]4([H])C[C@](C/C=C(C)/C[C@@H](C)/C=C/C=C2\CO3)([H])O[C@]5(O[C@H](C(C)C)[C@@H](C)CC5)C4
Formula C33H48O7 M.Wt 556.7
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.7963 mL 8.9815 mL 17.963 mL
5 mM 0.3593 mL 1.7963 mL 3.5926 mL
10 mM 0.1796 mL 0.8981 mL 1.7963 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for Milbemycin D

Average Rating: 5 ★★★★★ (Based on Reviews and 24 reference(s) in Google Scholar.)

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