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Naphthyridine carbamate dimer

Catalog No.GC71263

Naphthyridine carbamate dimer est une colle moléculaire d’adn qui induit des changements structuraux conçus dans l’adn fonctionnel cible pour moduler la fonction.

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Naphthyridine carbamate dimer Chemical Structure

Cas No.: 864627-58-7

Taille Prix Stock Qté
1 mg
270,00 $US
En stock
5 mg
675,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Description of Naphthyridine carbamate dimer

Naphthyridine caebamate dimer (NCD) is a DNA molecular glue that induces designed structural changes in target functional DNA to modulate function.

References:
[1]. Yamada T, et, al. NMR determination of the 2:1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA. Nucleic Acids Res. 2022 Sep 23;50(17):9621-9631.
[2]. Simeth NA, et, al. Rational design of a photoswitchable DNA glue enabling high regulatory function and supramolecular chirality transfer. Chem Sci. 2021 May 27;12(26):9207-9220.

Chemical Properties of Naphthyridine carbamate dimer

Cas No. 864627-58-7 SDF
Formula C26H29N7O4 M.Wt 503.55
Solubility Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Naphthyridine carbamate dimer

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1 mg 5 mg 10 mg
1 mM 1.9859 mL 9.9295 mL 19.859 mL
5 mM 0.3972 mL 1.9859 mL 3.9718 mL
10 mM 0.1986 mL 0.993 mL 1.9859 mL
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In vivo Formulation Calculator (Clear solution) of Naphthyridine carbamate dimer

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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