Pregnanediol |
| Catalog No.GC39185 |
Pregnanediol est le principal métabolite de la progestérone, excrété dans l'urine.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 80-92-2
Sample solution is provided at 25 µL, 10mM.
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Pregnanediol est le principal métabolite de la progestérone, excrété dans l'urine[1]. Pregnanediol excrété par les femmes enceintes peut réfléter la fonction du placenta, et la progestérone urinaire peut être utilisée pour évaluer la fonction des ovaires[2]. Pregnanediol peut être utilisé en tant que substance de référence pour développer de nouvelles méthodes de détection afin d'améliorer l'identification de composés apparentés[3]. Lorsque des embryons de poisson-zèbre sont exposés à l'eau usée contenant 300ng/l de Pregnanediol pendant 48 heures, la fréquence de contraction musculaire spontanée est diminuée significativement et la fréquence cardiaque des embryons est significativement réduite[4].
References:
[1] Usuki S, Kondoh K, Kubo T. Plasma endothelin and LH-RH, LH, FSH, prolactin, progesterone, 17α-hydroxyprogesterone, estrone, 17β-estradiol, Δ4-androstenedione, testosterone, active renin, angiotensin-II and ANP levels in blood and LH, estrone and 17β-estradiol and pregnanediol levels in urine of normal cycling women[J]. Journal of Cardiovascular Pharmacology, 2000, 36: S421-S427.
[2] Haran S, Chindera K, Sabry M, et al. Natural Killer Cell Dysfunction in Premenopausal BRCA1 Mutation Carriers: A Potential Mechanism for Ovarian Carcinogenesis[J]. Cancers, 2024, 16(6): 1186.
[3] Zhang K, Fent K. Determination of two progestin metabolites (17α-hydroxypregnanolone and pregnanediol) and different classes of steroids (androgens, estrogens, corticosteroids, progestins) in rivers and wastewaters by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)[J]. Science of the Total Environment, 2018, 610: 1164-1172.
[4] Zhang K, Zhao Y, Fent K. Occurrence and ecotoxicological effects of free, conjugated, and halogenated steroids including 17α-hydroxypregnanolone and pregnanediol in Swiss wastewater and surface water[J]. Environmental science & technology, 2017, 51(11): 6498-6506.
| Cas No. | 80-92-2 | SDF | |
| Canonical SMILES | C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C[C@H](O)CC2)([H])[C@@]4([H])[C@@](C)([C@]([C@@H](O)C)([H])CC4)CC3 | ||
| Formula | C21H36O2 | M.Wt | 320.51 |
| Solubility | Ethanol: 5 mg/mL (15.60 mM); DMSO: 2 mg/mL (6.24 mM); Water: < 0.1 mg/mL (insoluble) | Storage | Store at RT |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.12 mL | 15.6001 mL | 31.2003 mL |
| 5 mM | 624 μL | 3.12 mL | 6.2401 mL |
| 10 mM | 312 μL | 1.56 mL | 3.12 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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