Accueil>>Modified Nucleotides>>Pseudo-UTP,100mM Tris Solution

Pseudo-UTP,100mM Tris Solution (Synonyms: Pseudouridine-5'-Triphosphate, 5-Ribosyl Uracil)

Catalog No.GB20003

Pseudo-UTP is a modified UTP derived through base isomerization reaction and is often used for drug synthesis of mRNA.

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Pseudo-UTP,100mM Tris Solution Chemical Structure

Taille Prix Stock Qté
10ul
40,00 $US
En stock
50ul
120,00 $US
En stock
100ul
180,00 $US
En stock
1mL
650,00 $US
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10mL Please Inquire Please Inquire
100mL Please Inquire Please Inquire
500mL
0,10 $US
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Pseudo-UTP is derived from UTP through base isomerization reaction, which can perform complementary base pairing with adenosine like uridine, and change the structure of RNA by improving base pairing, base stacking and main chain stability [1]. The mRNA in which Pseudo-UTP completely replaces UTP exhibits lower immunogenicity, higher stability and translation ability [2].

References:
[1]. Yi-Tao Yu. RNA-guided isomerization of uridine to pseudouridine-pseudouridylation. Clin Chim Acta. 2014;11(12):1483-94. doi: 10.4161/15476286.2014.972855. PMCID: PMC4615163.
[2]. Muthian Shanmugasundaram, et al. An Efficient Protection-Free One-Pot Chemical Synthesis of Modified Nucleoside-5'-Triphosphates. Nucleosides Nucleotides Nucleic Acids. 2016 Jul 2;35(7):356-62.

Chemical Properties

Cas No. SDF
Synonymes Pseudouridine-5'-Triphosphate, 5-Ribosyl Uracil
Chemical Name (5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
Canonical SMILES O=C(NC1=O)NC=C1C2C(C(C(O2)COP(O)(OP(O)(OP(O)(O)=O)=O)=O)O)O
Formula C9H15N2O15P3 M.Wt 484
Solubility A solution of water Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.0661 mL 10.3306 mL 20.6612 mL
5 mM 0.4132 mL 2.0661 mL 4.1322 mL
10 mM 0.2066 mL 1.0331 mL 2.0661 mL
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