Pseudo-UTP,100mM Tris Solution (Synonyms: Pseudouridine-5'-Triphosphate, 5-Ribosyl Uracil) |
Catalog No.GB20003 |
Pseudo-UTP is a modified UTP derived through base isomerization reaction and is often used for drug synthesis of mRNA.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Pseudo-UTP is derived from UTP through base isomerization reaction, which can perform complementary base pairing with adenosine like uridine, and change the structure of RNA by improving base pairing, base stacking and main chain stability [1]. The mRNA in which Pseudo-UTP completely replaces UTP exhibits lower immunogenicity, higher stability and translation ability [2].
References:
[1]. Yi-Tao Yu. RNA-guided isomerization of uridine to pseudouridine-pseudouridylation. Clin Chim Acta. 2014;11(12):1483-94. doi: 10.4161/15476286.2014.972855. PMCID: PMC4615163.
[2]. Muthian Shanmugasundaram, et al. An Efficient Protection-Free One-Pot Chemical Synthesis of Modified Nucleoside-5'-Triphosphates. Nucleosides Nucleotides Nucleic Acids. 2016 Jul 2;35(7):356-62.
Cas No. | SDF | ||
Synonymes | Pseudouridine-5'-Triphosphate, 5-Ribosyl Uracil | ||
Chemical Name | (5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate | ||
Canonical SMILES | O=C(NC1=O)NC=C1C2C(C(C(O2)COP(O)(OP(O)(OP(O)(O)=O)=O)=O)O)O | ||
Formula | C9H15N2O15P3 | M.Wt | 484 |
Solubility | A solution of water | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 2.0661 mL | 10.3306 mL | 20.6612 mL |
5 mM | 0.4132 mL | 2.0661 mL | 4.1322 mL |
10 mM | 0.2066 mL | 1.0331 mL | 2.0661 mL |
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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