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(R)-(+)-Atenolol (Synonyms: (R)-Atenolol)

Catalog No.GC11952

Le (R)-(+)-aténolol est l'énantiomère le moins actif du (R,S)-aténolol.

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(R)-(+)-Atenolol Chemical Structure

Cas No.: 56715-13-0

Taille Prix Stock Qté
1mg
23,00 $US
En stock
5mg
99,00 $US
En stock
10mg
180,00 $US
En stock
25mg
382,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(R)-(+)-Atenolol is the less active enantiomer of the racemic β1-adrenergic receptor antagonist, (R, S)-atenolol [1].

Atenolol is a selective β1 receptor antagonist, a drug belonging to the group of beta blockers, a class of drugs used primarily in cardiovascular diseases. Atenolol is used for a number of conditions including hypertension, angina, long QT syndrome, acute myocardial infarction, supraventricular tachycardia, ventricular tachycardia, and the symptoms of alcohol withdrawal. β1-adrenergic receptor is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein and is expressed predominantly in cardiac tissue.

Pharmacokinetic data of the time course of plasma concentrations over 24 h following oral administration of 50 mg (R)-(+)-Atenolol revealed that the Cmax, AUC, and t1/2 values were 326±87 ng/ml, 2599±639 ng×h/ml, and 8.9±2.9 h, respectively [1].

Reference:
[1] Stoschitzky K, Egginger G, Zernig G, et al.  Stereoselective features of (R)- and (S)-atenolol: clinical pharmacological, pharmacokinetic, and radioligand binding studies[J]. Chirality, 1993, 5(1): 15-19.

Chemical Properties

Cas No. 56715-13-0 SDF
Synonymes (R)-Atenolol
Chemical Name 4-[(2R)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-benzeneacetamide
Canonical SMILES NC(CC1=CC=C(OC[C@H](O)CNC(C)C)C=C1)=O
Formula C14H22N2O3 M.Wt 266.3
Solubility ≤5mg/ml in ethanol;15mg/ml in DMSO;20mg/ml in dimethyl formamide Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.7552 mL 18.7758 mL 37.5516 mL
5 mM 0.751 mL 3.7552 mL 7.5103 mL
10 mM 0.3755 mL 1.8776 mL 3.7552 mL
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