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(R)-PS210

Catalog No.GC63802

(R)-PS210, l'énantiomère R de PS210 (composé 4h-eutomère), est un activateur allostérique sélectif du substrat de PDK1 avec une valeur AC50 de 1,8 μM. (R)-PS210 cible la poche de liaison PIF dePDK1. PIF : Fragment interagissant avec la kinase 2 liée À la protéine kinase C (PRK2).

Products are for research use only. Not for human use. We do not sell to patients.

(R)-PS210 Chemical Structure

Cas No.: 1410101-89-1

Taille Prix Stock Qté
5 mg
225,00 $US
En stock
10 mg
351,00 $US
En stock
25 mg
702,00 $US
En stock
50 mg
1 125,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment[1].

(R)-PS210 displays an AC50 value of 1.8 μM towards PDK1 in a Cell-Free Kinase Activity Assay. And the maximum activation of PDK1 compared to DMSO control of (R)-PS210 is 5.5 fold[1].

[1]. Wilhelm A, et al. 2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept.J Med Chem. 2012 Nov 26;55(22):9817-30.

Chemical Properties

Cas No. 1410101-89-1 SDF Download SDF
Formula C19H15F3O5 M.Wt 380.31
Solubility DMSO : 230 mg/mL (604.77 mM; Need ultrasonic) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.6294 mL 13.1472 mL 26.2943 mL
5 mM 0.5259 mL 2.6294 mL 5.2589 mL
10 mM 0.2629 mL 1.3147 mL 2.6294 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 37 reference(s) in Google Scholar.)

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