Neuroscience
Neuroscience
Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).
Targets for Neuroscience
- 5-HT Receptor(549)
- AChR(62)
- AChE(114)
- Alzheimer(109)
- Amyloid β(157)
- BACE(5)
- CGRP (33)
- COX(306)
- DAPK(6)
- Dopamine Receptor(319)
- GABA Receptor(239)
- Gap Junction(23)
- GluR(121)
- Histamine(4)
- Histamine Receptor(241)
- mPEGS-1(5)
- Muscarinic Receptor(46)
- Neuroscience Peptides(94)
- Nicotinic Receptor(70)
- P2 Receptor(2)
- P2X7 receptor(5)
- SSRIs(8)
- Substance P/NK1 Receptor(22)
- NMDA(2)
- Cholecystokinin Receptor(22)
- GPR139(3)
- mAChR(139)
- MCHR1 (GPR24)(15)
- Neurokinin Receptor(60)
- iGluR(139)
- nAChR(66)
- Beta-secretase(26)
- CaMK(33)
- Dopamine Transporter(17)
- Monoamine Oxidase(84)
- Serotonin Transporter(57)
- Behavioral Neuroscience(274)
- DREADD(0)
- Huntington(10)
- Neuroendocrinology(39)
- Neuroprotection(81)
- Ophthalmology(116)
- Pain Research(166)
- Parkinson(49)
- Seizure Disorders(74)
- Prion(6)
- Cholinesterases(13)
Products for Neuroscience
- Cat.No. Nom du produit Informations
- GC18022 (S)-Flurbiprofen Le (S)-flurbiprofène est un énantiomère actif du flurbiprofène, avec des valeurs IC50 de 0,48 μM et 0,47 μM pour COX-1 et COX-2, respectivement.
- GC10739 (S)-HexylHIBO Group I mGlu receptor antagonist
- GC15977 (S)-Ketoprofen Le (S)-kétoprofène est un puissant inhibiteur de la COX-1 et de la COX-2 avec des CI50 de 1,9 et 27 nM, respectivement.
- GC41389 (S)-Ketorolac Le (S)-kétorolac est un agent anti-inflammatoire non stéroÏdien.
- GC41738 (S)-KT109 (S)-KT109 is the (S) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109.
- GC40145 (S)-Laudanosine (S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium.
- GC16349 (S)-MCPG Le (S)-MCPG ((+)-MCPG) est un puissant antagoniste des récepteurs métabotropiques du glutamate de groupe I/II (mGluRs) et l'isomère actif du (RS)-MCPG.
- GC67989 (S)-Mirtazapine
- GC68410 (S)-Mirtazapine-d3
- GC14820 (S)-Naproxen Le (S)-naproxène est un inhibiteur de la COX-1 et de la COX-2 avec des CI50 de 8,72 et 5,15 μM, respectivement dans le test cellulaire.
- GC49179 (S)-O-Desmethyl Naproxen A metabolite of (S)-naproxen
- GC46355 (S)-Pramipexole-d5 (hydrochloride) An internal standard for the quantification of (S)-pramipexole
- GC33686 (S)-Rasagiline (TVP1022) La (S)-Rasagiline (TVP1022) (TVP1022) est la forme énantiomère S relativement inactive de la Rasagiline.
- GC35006 (S)-Rasagiline mesylate Le mésylate de (S)-rasagiline (TVP1022) est la forme énantiomère S relativement inactive du mésylate de rasagiline.
-
GC69941
(S)-Renzapride
(S)-Renzapride ((S)-BRL 24924) est l'isomère de Renzapride. Renzapride est un agoniste des récepteurs 5-HT4 avec une valeur Ki de 115 nM. Renzapride est également un antagoniste des récepteurs 5HT2b et 5HT3. Renzapride peut être utilisé dans la recherche sur le syndrome du côlon irritable à prédominance constipation (C-IBS).
- GC15464 (S)-SNAP 5114 (S)-SNAP 5114 est un inhibiteur sélectif du transport du GABA, avec des valeurs IC50 de 5 μM et 21 μM pour hGAT-3 et rGAT-2, respectivement.
- GC60424 (S)-Venlafaxine La (S)-venlafaxine est la configuration (S) de la venlafaxine. La venlafaxine est un double inhibiteur de la recapture de la sérotonine (5-HT)/norépinéphrine (NE) actif par voie orale. La venlafaxine est un antidépresseur.
-
GC69979
(S)-VQW-765
(S)-VQW-765 ((S)-AQW-051) est un agoniste partiel sélectif et efficace des récepteurs nicotiniques de l'acétylcholine (nAChR) α7, ayant une activité orale. Le (S)-VQW-765 a un potentiel d'application dans les troubles cognitifs associés aux maladies neurologiques telles que la maladie d'Alzheimer ou la schizophrénie.
- GC14805 (S)-WAY 100135 dihydrochloride 5-HT1A receptor antagonist,potent and selective
-
GC30212
(S)-Willardiine ((-)-Willardiine)
(S)-Willardiine ((-)-Willardiine) est un agoniste puissant des récepteurs AMPA/kainate avec une EC50 de 44,8 uM.
- GC35011 (Z)-Thiothixene Le (Z)-thiothixène est un antagoniste du récepteur sérotoninergique extrait du brevet US 20150141345 A1.
- GC18596 (±)-2-propyl-4-Pentenoic Acid L'acide (±)-2-propyl-4-penténoÏque (4-en-VPA) est un métabolite toxique majeur de l'acide valproÏque.
- GC12774 (±)-Anatoxin A fumarate (±)-Le fumarate d'anatoxine A est un alcaloïde naturel isolé de la cyanobactérie d'eau douce.
- GC12927 (±)-Baclofen Le (±)-baclofène, un dérivé lipophile de l'acide γ-aminobutyrique (GABA), est un agoniste sélectif du récepteur métabotrope GABAB (GABABR) actif par voie orale.
- GC11965 (±)-Huperzine A A neuroprotective AChE inhibitor
- GC13786 (±)-Salsolinol (hydrochloride) depolarize dopamineric neurons
- GC14252 (–)-Stepholidine A dopamine receptor antagonist and 5-HT1A partial agonist
- GC49034 1(R)-(Trifluoromethyl)oleyl alcohol An oleic acid analog
- GC46366 1,2,3,4-Tetrahydro-β-carboline A serotonin reuptake inhibitor and metabolite of tryptamine
- GC45698 1,2,3-Triheptanoyl-rac-glycerol Le 1,2,3-triheptanoyl-rac-glycérol (propane-1,2,3-triyl triheptanoate) est un triglycéride synthétique À chaÎne moyenne (MCT) composé de trois acides gras À chaÎne impaire À 7 carbones (heptanoate) sur un glycérol colonne vertébrale.
- GC41774 1,2,3-Trimyristoyl-rac-glycerol Le 1,2,3-trimyristoyl-rac-glycérol, un composant molluscicide actif de Myristica fragransHoutt, inhibe de manière significative les activités de l'acétylcholinestérase (AChE), de la phosphatase acide et alcaline (ACP/ALP) dans le tissu nerveux de Lymnaea acuminata.
- GC46009 1,2,3-Trioctanoyl-rac-glycerol-13C3 An internal standard for the quantification of 1,2,3-trioctanoyl glycerol-13C3
- GC18334 1,2-Dierucoyl-sn-glycero-3-PC Le 1,2-Dierucoyl-sn-glycéro-3-PC (DEPC) est la composition de la membrane des liposomes.
- GC42050 1-β-D-Glucosylsphingadienine (d18:2 (4E,8E)) 1-β-D-Glucosylsphingadiénine (d18:2 (4E,8E)) est une glucosylsphingosine, qui sont des dérivés lysolipidiques désacétylés de glucosylcérébrosides.
- GC42051 1-β-D-Glucosylsphingosine (d18:1) 1-β-D-Glucosylsphingosine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucocerebrosides.
- GC12587 1-(1-Naphthyl) piperazine (hydrochloride) ligand for 5-HT receptors
- GC41751 1-(3,5-Dimethylphenyl)piperazine 1-(3,5-Dimethylphenyl)piperazine is a piperidine compound that is inactive at dopamine and serotonin receptors.
- GC49346 1-(3-Chlorophenyl)biguanide (hydrochloride) A 5-HT3 receptor agonist
-
GC16031
1-(3-Chlorophenyl)piperazine (hydrochloride)
5-HT2C/2B receptor agonist/partial agonist
- GC49294 1-(4-Chlorobenzhydryl)piperazine An inactive metabolite of meclizine and chlorcyclizine
- GC41761 1-(6-Methoxy-2-naphthyl)ethanol 1-(6-Methoxy-2-naphthyl)ethanol is a potential impurity in commercial preparations of naproxen.
- GC18009 1-Acetyl-4-methylpiperazine hydrochloride nAChR agonist
- GC12863 1-BCP Le 1-BCP (pipéridide d'acide pipéronylique) est un médicament À action centrale qui module les courants déclenchés par les récepteurs AMPA.
- GC49861 1-Carboxycyclohexaneacetic Acid A potential impurity in commercial preparations of gabapentin
- GC46050 1-Deoxysphingosine (m18:1(4E)) An atypical sphingolipid
- GC60447 1-Hydroxy-ibuprofen Le 1-hydroxy ibuprofène est un métabolite de l'ibuprofène chez P.
- GC14607 1-Methylpsilocin 5-HT2C agonist,potent and selective
- GC38698 1-Naphthyl acetate L'acétate de 1-naphtyle est un substrat chromogénique intéressant pour la détection de l'activité de l'acétylcholinestérase érythrocytaire (AChE).
- GC49818 1-Octen-3-ol Le 1-Octen-3-ol, un acide gras parfumé, est un messager auto-stimulant de l'oxylipine.
- GC40910 1-Oleoyl-2-hydroxy-sn-glycero-3-PE 1-Oleoyl-2-hydroxy-sn-glycero-3-PE is a naturally-occurring lysophospholipid and an analog of plasmalogen lysophosphatidylethanolamine.
- GC45979 1-Palmitoyl-2-Oleoyl-3-Arachidonoyl-rac-glycerol A triacylglycerol
- GC16876 1-Phenylbiguanide hydrochloride 5-HT3 receptor agonist
- GC49366 1-Salicylate Glucuronide A metabolite of salicylic acid and aspirin
- GC49088 1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE A phospholipid
- GC42045 1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC is a phospholipid containing stearic acid and docosahexaenoic acid at the sn-1 and sn-2 positions, respectively.
- GC40176 1-Stearoyl-rac-glycerol 1-Stearoyl-rac-glycerol is a monoacylglycerol that contains stearic acid at the sn-1 position.
- GC49820 10,11-dihydro-10,11-dihydroxy Carbamazepine A metabolite of carbamazepine and oxcarbazepine
- GC13863 10Panx A peptide inhibitor of PANX1
- GC46412 11β-Prostaglandin F2α-d4 An internal standard for the quantification of 11β-PGF F2α
-
GC18798
11-cis Retinal
11-cis Retinal is a chromophore that binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin.
- GC48821 11-cis Retinol An isomer of vitamin A
-
GC18637
11β-Prostaglandin F2α
11β-Prostaglandin F2α (11β-PGF2α) is the primary plasma metabolite of PGD2 in vivo.
- GC49808 12-methyl Tridecanoic Acid A methylated fatty acid
- GC18783 13,14-dihydro-15-keto Prostaglandin E1 13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity.
- GC41910 13-Docosenamide 13-Docosenamide is the amide of docosenoic acid.
- GC41907 13C C16 Sphingomyelin (d18:1/16:0) 13C C16 Sphingomyelin is an isotopically enriched form of C16 sphingomyelin with carbon-13 occurring on the fatty acid portion.
- GC41908 13C6 Glucosylsphingosine (d18:1) 13C6 Glucosylsphingosine (d18:1) is an isotopically enriched form of 1-β-D-glucosylsphingosine (d18:1) that is intended for use as an internal standard for the quantification of 1-β-D-glucosylsphingosine by GC- or LC-MS.
- GC46437 14-dehydro Zymostenol A cholesterol precursor
- GC40988 15(R)-17-phenyl trinor Prostaglandin F2α 17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2α ethyl amide.
- GC41922 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15.
- GC41093 15(S)-Latanoprost 15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost.
- GC49036 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α A nitric oxide-donating derivative of 17-phenyl trinor prostaglandin F2α
- GC41934 15-keto Latanoprost Le 15-céto latanoprost est un métabolite du latanoprost, qui est un hypotenseur oculaire.
- GC40989 15-keto Latanoprost (free acid) 15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals.
- GC41936 15-keto-17-phenyl trinor Prostaglandin F2α Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.
- GC41937 15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug.
- GC41947 16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide The actions of many clinical F-series prostaglandins (PGs), including those used for estrous synchronization and for reduction of intraocular pressure (IOP), are mediated through the PGF2α (FP) receptor.
- GC41948 16-phenoxy tetranor Prostaglandin F2α isopropyl ester Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor.
- GC40961 16-phenoxy tetranor Prostaglandin F2α methyl ester Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor.
- GC46451 16F16 A PDI inhibitor
- GC41207 17(R)-HDHA Resolvins are a group of polyhydroxylated metabolites of docosahexaenoic acid (DHA) found in the inflammatory exudates of aspirin-treated experimental animals.
- GC41208 17(S)-HDHA 17(S)-HDHA is a primary mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, and mouse brain.
- GC17223 17-PA Le 17-PA est un antagoniste sélectif de la potentialisation des neurostéroÏdes et de la synchronisation directe des récepteurs GABAA .
- GC41960 17-phenoxy trinor Prostaglandin F2α ethyl amide Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.
- GC40990 17-phenyl trinor Prostaglandin F2α 17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor.
- GC41967 17-phenyl trinor Prostaglandin F2α amide 17-phényl trinor Prostaglandine F2α l'amide est un métabolite N-déséthylé du bimatoprost.
- GC41969 17-phenyl trinor Prostaglandin F2α cyclopropyl amide 17-phenyl trinor Prostaglandin F2α cyclopropyl amide (17-phenyl trinor PGF2α cyclopropyl amide) is a novel analog of 17-phenyl trinor PGF2α ethyl amide.
- GC41970 17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide Prostaglandin F2α (PGF2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis.
- GC41971 17-phenyl trinor Prostaglandin F2α diethyl amide 17-phenyl trinor Prostaglandin F2α diethyl amide (17-phenyl trinor PGF2α diethyl amide) is an analog of PGF2α in which the C-1 carboxyl group has been modified to an N-diethyl amide.
- GC46458 17-phenyl trinor Prostaglandin F2α dimethyl amide An isomer of 17-phenyl trinor prostaglandin F2α ethyl amide
- GC41972 17-phenyl trinor Prostaglandin F2α isopropyl ester 17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost.
- GC41973 17-phenyl trinor Prostaglandin F2α methyl amide 17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor, binding with a relative potency of 756% compared to that of PGF2α.
- GC40392 17-phenyl trinor Prostaglandin F2α methyl ester 17-phényl trinor Prostaglandine F2α l'ester méthylique est une prodrogue du bimatoprost.
- GC46463 17-phenyl trinor Prostaglandin F2α-d4 An internal standard for the quantification of bimatoprost (free acid)
- GC41975 17-trifluoromethylphenyl trinor Prostaglandin F2α A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.
- GC41976 17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.
- GC41978 17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.
- GC46466 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α A prostaglandin F derivative similar to latanoprost free acid
- GC49823 2′-C-β-Methylguanosine An active nucleoside metabolite of BMS-986094
- GC60017 2'-O-Methylisoliquiritigenin La 2'-O-méthylisoliquiritigénine, isolée de l'espèce Arachis, régule À la hausse les voies 5-HT, NE, DA et GABA, mais n'exerce pas d'effet très significatif sur la voie ne NE .