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Accueil >> Signaling Pathways >> Proteases >> Mitochondrial Metabolism

Mitochondrial Metabolism

Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids. These carbon fuels feed into the TCA cycle in the mitochondrial matrix to generate the reducing equivalents NADH and FADH2, which deliver their electrons to the electron transport chain. Mitochondria are complex organelles that play an important role in many facets of cellular function, from metabolism to immune regulation and cell death. Mitochondria are actively involved in a wide variety of cellular processes and molecular interactions, such as calcium buffering, lipid flux, and intracellular signaling. It is increasingly recognized that mitochondrial dysfunction is a hallmark of many diseases such as obesity/diabetes, cancer, cardiovascular and neurodegenerative diseases. Mitochondrial metabolism is a key determinant of tumor progression by impacting on functions such as epithelial-to-mesenchymal transition. Mitochondrial metabolism and derived oncometabolites shape the epigenetic landscape to alter aggressiveness features of cancer cells. Changes in mitochondrial metabolism are relevant for the survival of tumors in response to therapy.

Targets for  Mitochondrial Metabolism

Products for  Mitochondrial Metabolism

  1. Cat.No. Nom du produit Informations
  2. GC19941 DL-Leucic Acid DL-Leucic Acid Chemical Structure
  3. GC40539 (±)12(13)-EpOME

    (±)12,13-EODE, Isoleukotoxin, (±)-Vernolic Acid

     (±)12(13)-EpOME is the 12,13-cis epoxide of linoleic acid, generated by neutrophils during the oxidative burst. (±)12(13)-EpOME Chemical Structure
  4. GC40801 (±)9(10)-DiHOME

    Leukotoxin diol

     (±)9(10)-DiHOME est le racémate de 9,10-DiHOME. (±)9(10)-DiHOME Chemical Structure
  5. GC14049 (-)-Epigallocatechin gallate (EGCG)

    EGCG

     (-)-Epigallocatechin gallate (EGCG) est un polyphénol majeur du thé vert qui inhibe la prolifération cellulaire et induit l'apoptose. (-)-Epigallocatechin gallate (EGCG) Chemical Structure
  6. GC41721 (R)-α-Lipoic Acid

    (R)-(+)-Lipoic Acid

     (R)-α-Lipoic acid is the naturally occurring enantiomer of lipoic acid, a cyclic disulfide antioxidant. (R)-α-Lipoic Acid Chemical Structure
  7. GC18596 (±)-2-propyl-4-Pentenoic Acid

    2-Allylpentanoic Acid, 4-ene VPA

    L'acide (±)-2-propyl-4-penténoÏque (4-en-VPA) est un métabolite toxique majeur de l'acide valproÏque. (±)-2-propyl-4-Pentenoic Acid Chemical Structure
  8. GC19528 1,4-Benzoquinone

    p-Benzoquinone, NSC 36324, p-Quinone

     A toxic metabolite of benzene 1,4-Benzoquinone Chemical Structure
  9. GC49872 10-Formyltetrahydrofolate (sodium salt) (technical grade)

    10-CHO-FH4, 10-CHO-THF, N10-Formyltetrahydrofolate, 10-formyl H4PteGlu, 10-fTHF

     Le 10-formyltétrahydrofolate (sel de sodium) (qualité technique) est une forme d'acide tétrahydrofolique qui agit comme donneur de groupes formyle dans l'anabolisme. 10-Formyltetrahydrofolate (sodium salt) (technical grade) Chemical Structure
  10. GC46451 16F16 A PDI inhibitor 16F16 Chemical Structure
  11. GC90815 2',3'-cyclic NADP+ (sodium salt)

    Un substrat pour CNP

     2',3'-cyclic NADP+ (sodium salt) Chemical Structure
  12. GC90803 2',3'-Dideoxyadenosine-5'-O-triphosphate (sodium salt)

    Un inhibiteur de la transcriptase inverse et un métabolite actif de ddA et ddI.

     2',3'-Dideoxyadenosine-5'-O-triphosphate (sodium salt) Chemical Structure
  13. GC42193 2-Thenoyltrifluoroacetone

    NSC 66544, NSC 405702, NSC 405703, NSC 405704, NSC 405705, NSC 405706, TTFA

     La 2-thénoyltrifluoroacétone est un agent chélateur. 2-Thenoyltrifluoroacetone Chemical Structure
  14. GC49849 3-Aminosalicylic Acid

    3-ASA, NSC 285111

     A salicylic acid derivative 3-Aminosalicylic Acid Chemical Structure
  15. GC45615 3-hydroxy-3-methylglutaryl Coenzyme A (sodium salt)

    DL-3-hydroxy-3-methylglutaryl-CoA, HMG-CoA, Hydroxymethylglutaryl-CoA

     A neuropeptide with diverse biological activities 3-hydroxy-3-methylglutaryl Coenzyme A (sodium salt) Chemical Structure
  16. GC46599 3-hydroxy-3-methylglutaryl-Coenzyme A-d3 (ammonium salt)

    DL-3-hydroxy-3-methylglutaryl-CoA-d3, HMG-CoA-d3, Hydroxymethylglutaryl-CoA-d3

     A neuropeptide with diverse biological activities 3-hydroxy-3-methylglutaryl-Coenzyme A-d3 (ammonium salt) Chemical Structure
  17. GC42351 4-carboxy TEMPO

    4-Carboxyl-2,2,6,6-tetramethylpiperidin-1-oxyl

     4-carboxy TEMPO is a nitroxide and spin label. 4-carboxy TEMPO Chemical Structure
  18. GC49722 4-CF3-TPP-DC

    4-CF3-Triphenylphosphonium-DC

     An inert mitochondriotropic carrier 4-CF3-TPP-DC Chemical Structure
  19. GC41310 5-Octyl-α-ketoglutarate

    αKG octyl ester

     In addition to its role in the Krebs cycle, α-ketoglutarate (2-oxoglutarate) has roles as a substrate or modulator of enzymes. 5-Octyl-α-ketoglutarate Chemical Structure
  20. GC46779 Acequinocyl A naphthoquinone acaricide Acequinocyl Chemical Structure
  21. GC42695 Acetoacetyl Coenzyme A (sodium salt hydrate)

    Acetoacetyl-CoA

    Acetoacetyl coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway.

     Acetoacetyl Coenzyme A (sodium salt hydrate) Chemical Structure
  22. GC46789 Acetyl-L-carnitine-d3 (chloride)

    ALCAR-d3, L-Acetylcarnitine-d3, C2:0 Carnitine-d3, CAR 2:0-d3, L-Carnitine acetyl ester-d3

     An internal standard for the quantification of L-acetylcarnitine Acetyl-L-carnitine-d3 (chloride) Chemical Structure
  23. GC19021 Adjudin

    AF-2364

     Adjudin est un contraceptif masculin largement étudié avec un effet supérieur d'inhibition des mitochondries. Adjudin est également un puissant bloqueur du canal Cl. Adjudin Chemical Structure
  24. GC42742 ADT-OH

    ACS1

     L'ADT-OH est un donneur libérant du sulfure d'hydrogène. L'ADT-OH induit l'apoptose et inhibe le développement du mélanome in vivo en régulant À la hausse le FADD. ADT-OH a le potentiel pour la recherche sur les maladies cancéreuses. ADT-OH Chemical Structure
  25. GC46812 Aflatoxin G1-13C17 An internal standard for the quantification of aflatoxin G1 Aflatoxin G1-13C17 Chemical Structure
  26. GC46814 Aflatoxin M1-13C17

    AFM1-13C17

     A neuropeptide with diverse biological activities Aflatoxin M1-13C17 Chemical Structure
  27. GC35262 Afzelin

    Kaempferin, Kaempferol 3-O-rhamnoside, Kaempferol 3-O-α-L-rhamnopyranoside

     Afzelin (Kaempferol-3-O-rhamnoside) est un glycoside de flavonol trouvé dans Houttuynia cordata Thunberg et est largement utilisé dans la préparation d'agents antibactériens et antipyrétiques, de détoxifiants et pour le traitement de l'inflammation. Afzelin Chemical Structure
  28. GC63642 Agaric acid L'acide agarique (acide agaricinique) est obtenu À partir de diverses plantes de la tribu des champignons, c'est-À-dire. Agaric acid Chemical Structure
  29. GC18437 Alternariol monomethyl ether

    AME, NSC 638262

     L'éther monométhylique d'alternariol, isolé des racines d'Anthocleista djalonensis (Loganiaceae), est un important marqueur taxonomique de l'espèce végétale. Alternariol monomethyl ether Chemical Structure
  30. GC18274 Amiprofos-methyl

    APM, NSC 313446

     L'amiprofos-méthyl (BAY-NTN 6867) est un herbicide à base d'amide phosphorique. Amiprofos-methyl Chemical Structure
  31. GC42818 Antimycin A1 L'antimycine A1 est un inhibiteur spécifique du transfert d'électrons de l'ubiquinol-cytochrome c oxydoréductase. L'antimycine A1 inhibe l'angiogenèse par diminution de la production de VEGF causée par l'inhibition de l'activation de HIF-1α. Antimycin A1 Chemical Structure
  32. GC18621 Antimycin A2 Antimycin A2 is an active component of the antimycin A antibiotic complex. Antimycin A2 Chemical Structure
  33. GC42819 Antimycin A3 Antimycin A3 is a component of the antimycin A antibiotic complex that is more polar than antimycin A1 and antimycin A2 but not antimycin A4. Antimycin A3 Chemical Structure
  34. GC42820 Antimycin A4 Antimycin A4 is an active component of the antimycin A antibiotic complex that is more polar than antimycin A1, antimycin A2, and antimycin A3. Antimycin A4 Chemical Structure
  35. GC42821 AP219 AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. AP219 Chemical Structure
  36. GC42823 AP39 AP39 est un anéthole dithioléthione dérivé du triphénylphosphonium et un donneur de sulfure d'hydrogène (H2S) ciblant les mitochondries. AP39 Chemical Structure
  37. GC42846 Arachidonoyl-L-carnitine (chloride)

    C20:4 Carnitine​

    Carnitine facilitates the transport of fatty acids into the mitochondria to be used in fatty acid metabolism.

     Arachidonoyl-L-carnitine (chloride) Chemical Structure
  38. GC46883 AS-2077715 An inhibitor of fungal complex III AS-2077715 Chemical Structure
  39. GC31432 Asp-AMS

    Asp-AMS, un analogue de l'aspartyl-adényle, est un inhibiteur de l'aspartyl-ARNt synthétase et également un fort inhibiteur compétitif de l'enzyme mitochondriale.

     Asp-AMS Chemical Structure
  40. GC42874 Aureothin

    Antibiotic 74A, BRN 0058476, JA 2814K, Mycolutein, Strain 58 substance

     Aureothin is a natural nitroaryl-substituted polyketide that exhibits antitumor, antifungal, and insecticidal activities. Aureothin Chemical Structure
  41. GC40677 Avenaciolide

    (±)-Avenaciolide

     Avenaciolide est un bis-γ-lactone antifongique trouvé dans Aspergillus avenaceus. Avenaciolide Chemical Structure
  42. GC18580 B355252 Le B355252, une petite molécule de phénoxy thiophène sulfonamide, est un puissant agoniste des récepteurs du NGF. B355252 Chemical Structure
  43. GC49901 BAY-179 BAY-179 est un inhibiteur puissant, sélectif et À réaction croisée du complexe I (IC50 = 79 μM). BAY-179 Chemical Structure
  44. GC49403 Benzarone

    L 2197, NSC 82134

     Benzarone (Fragivix) est un puissant inhibiteur du transporteur 1 de l'acide urique humain (hURAT1), avec une IC50 de 2,8 μM dans l'ovocyte. Benzarone Chemical Structure
  45. GC49318 Benzovindiflupyr A fungicide Benzovindiflupyr Chemical Structure
  46. GC41252 BI-6C9 BI-6C9 est un inhibiteur hautement spécifique du domaine d'interaction BH3 (Bid), qui empêche le potentiel de membrane externe mitochondriale (MOMP) et la fission mitochondriale, et protège les cellules de la libération du facteur induisant l'apoptose mitochondriale (AIF) et de la mort cellulaire indépendante de la caspase dans les neurones. 1]. BI-6C9 Chemical Structure
  47. GC72916 Biguanide Biguanide est un hypoglycémiant actif par voie orale. Biguanide Chemical Structure
  48. GC52355 BimS BH3 (51-76) (human) (trifluoroacetate salt)

    DMRPEIWIAQELRRIGDEFNAYYARR-OH, Bims (51-76)

     A Bim-derived peptide BimS BH3 (51-76) (human) (trifluoroacetate salt) Chemical Structure
  49. GC18408 BML-278 BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 uM. BML-278 Chemical Structure
  50. GC46943 Boscalid A broad-spectrum carboxamide fungicide Boscalid Chemical Structure
  51. GC42978 Bromamphenicol Bromamphenicol is a dibrominated derivative of the antibiotic chloramphenicol. Bromamphenicol Chemical Structure
  52. GC43030 C16 dihydro Ceramide (d18:0/16:0)

    Cer(d18:0/16:0) ; Ceramide (d18:0/16:0); N-hexadecanoyl-D-erythro-Dihydrosphingosine; N-Palmitoyl Sphinganine

    A bioactive sphingolipid

     C16 dihydro Ceramide (d18:0/16:0) Chemical Structure
  53. GC91157 C18

    Un inhibiteur covalent de GPX4

     C18 Chemical Structure
  54. GC48425 C18 D-threo Ceramide (d18:1/18:0)

    D-threo Cer(d18:1/18:0), D-threo Ceramide (d18:1/18:0), N-octadecanoyl-D-threo-Sphingosine, N-stearoyl-D-threo-Sphingosine

     A synthetic ceramide C18 D-threo Ceramide (d18:1/18:0) Chemical Structure
  55. GC49806 C18 Ganglioside GD3-d3 (ammonium salt)

    Disialosyllactosylceramide-d3, N-omega-CD3-Octadecanoyl Disialoganglioside GD3-d3

     An internal standard for the quantification of ganglioside GD3 C18 Ganglioside GD3-d3 (ammonium salt) Chemical Structure
  56. GC43050 C18 L-erythro Ceramide (d18:1/18:0)

    L-erythro Cer(d18:1/18:0), L-erythro Ceramide (d18:1/18:0), N-octadecanoyl-L-erythro-Sphingosine

     C18 L-erythro Ceramide is a naturally occurring ceramide and stereoisomer of C18 ceramide. C18 L-erythro Ceramide (d18:1/18:0) Chemical Structure
  57. GC43051 C18 L-threo Ceramide (d18:1/18:0)

    N-octadecanoyl-L-threo-Sphingosine, L-threo Cer(d18:1/18:0), L-threo Ceramide (d18:1/18:0)

     C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids. C18 L-threo Ceramide (d18:1/18:0) Chemical Structure
  58. GC43052 C18 Phytoceramide (t18:0/18:0)

    Cer(t18:0/18:0), Ceramide (t18:0/18:0), N-Octadecanoyl Phytosphingosine, C18:0 Phytoceramide, SPS, N-Stearoyl Phytosphingosine

     C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in S. C18 Phytoceramide (t18:0/18:0) Chemical Structure
  59. GC40141 C18 Phytoceramide-d3 (t18:0/18:0-d3)

    Cer(t18:0/18:0) - d3, Ceramide (t18:0/18:0)- d3, N-Octadecanoyl Phytosphingosine- d3, C18:0 Phytoceramide- d3, N-Stearoyl Phytosphingosine- d3

     C18 Phytoceramide-d3 (t18:0/18:0-d3) is intended for use as an internal standard for the quantification of C18 phytoceramide (t18:0/18:0) by GC- or LC-MS. C18 Phytoceramide-d3 (t18:0/18:0-d3) Chemical Structure
  60. GC43069 C22 Ceramide (d18:1/22:0)

    C22 Ceramide；Cer(d18:1/22:0)；Ceramide (d18:1/22:0)

     C22 Ceramide (d18:1/22:0) est un céramide à chaîne longue contenant de l'acide béhénatique, isolé de l'éponge de mer Haliclona koremella, et est un sphingolipide bioactif endogène. C22 Ceramide (d18:1/22:0) Chemical Structure
  61. GC43141 Carboxyatractyloside (potassium salt) Carboxyatractyloside is a natural heteroglucoside produced in some plants, including A. Carboxyatractyloside (potassium salt) Chemical Structure
  62. GC43195 CAY10703 Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. CAY10703 Chemical Structure
  63. GC47065 CAY10773 A derivative of sorafenib CAY10773 Chemical Structure
  64. GC14727 CCCP

    Carbonyl cyanide m-chlorophenyl hydrazone, NSC 88124

     Carbonylcyanide-3-chlorophenylhydrazone (CCCP) est un protonophore qui provoque un découplage du gradient de protons dans la membrane mitochondriale interne, inhibant ainsi le taux de synthèse de l'ATP. CCCP Chemical Structure
  65. GC65208 CCI-006 CCI-006 est un inhibiteur sélectif et un chimiosensibilisateur des cellules leucémiques réarrangées MLL, en inhibant la respiration mitochondriale entraÎnant une dépolarisation mitochondriale insurmontable et une réponse protéique dépliée pro-apoptotique (UPR) dans un sous-ensemble de cellules leucémiques MLL-r. CCI-006 Chemical Structure
  66. GC45410 cis-6-Hexadecenoic Acid-d19

    C16:1(6Z)-d19, C16:1Δ6-d19, C16:1ω10c-d19, Sapienic Acid-d19

       cis-6-Hexadecenoic Acid-d19 Chemical Structure
  67. GC47096 Citrinin-13C13

    (-)-Citrinin-13C13, CTN-13C13

     A neuropeptide with diverse biological activities Citrinin-13C13 Chemical Structure
  68. GC43289 Cochlioquinone B Cochlioquinone is a sesquiterpene metabolite originally isolated from C. Cochlioquinone B Chemical Structure
  69. GC47114 Coenzyme A (lithium salt hydrate)

    CoA

     An essential cofactor in enzymatic acetyl transfer reactions Coenzyme A (lithium salt hydrate) Chemical Structure
  70. GC43295 Coenzyme A (sodium salt hydrate)

    CoA

     Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A (sodium salt hydrate) Chemical Structure
  71. GC47116 Coenzyme Q10-d6

    CoQ10-d6, Ubidecarenone-d6, Ubiquinone-10-d6, Ubiquinone Q10-d6

    Un standard interne pour la quantification de CoQ10.

     Coenzyme Q10-d6 Chemical Structure
  72. GC43297 Coenzyme Q2

    CoQ2, Ubiquinone-2, Ubiquinone Q2

     Coenzyme Q10 is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. Coenzyme Q2 Chemical Structure
  73. GC49454 Complex 3 A fluorescent copper complex with anticancer activity Complex 3 Chemical Structure
  74. GC47123 Coumarin-Quinone Conjugate A fluorescent substrate for NADH:ubiquinone oxidoreductases Coumarin-Quinone Conjugate Chemical Structure
  75. GC91800 CPPA-TPP

    CPPA-Triphenylphosphonium,4-Cyano-4-(phenylcarbonothioylthio)pentanoic Acid-TPP,4-Cyano-4-(phenylcarbonothioylthio)pentanoic-Triphenylphosphonium

     CPPA-TPP is a chain transfer agent conjugated to the mitochondria-targeting moiety triphenylphosphonium (TPP). CPPA-TPP Chemical Structure
  76. GC19138 CTPI-2 CTPI-2 est un inhibiteur SLC25A1 porteur de citrate mitochondrial de troisième génération avec un KD de 3,5 μM. CTPI-2 Chemical Structure
  77. GC43345 Cyclohexanoyl Coenzyme A

    CHCoA, Cyclohexanecarboxyl-CoA

     Cyclohexanoyl coenzyme A (CHCoA) is an acyl CoA that contains a cyclohexane group. Cyclohexanoyl Coenzyme A Chemical Structure
  78. GC49863 Cytarabine 5′-monophosphate

    ara-CMP, 1-β-D-Arabinofuranosylcytosine 5'-monophosphate, Cytosine Arabinoside monophosphate, NSC 99445

     An active metabolite of cytarabine Cytarabine 5′-monophosphate Chemical Structure
  79. GC45800 Cytarabine-13C3

    Ara-C-13C3, 1-β-D-Arabinofuranosylcytosine-13C3

     A neuropeptide with diverse biological activities Cytarabine-13C3 Chemical Structure
  80. GC25337 D-Carnitine hydrochloride

    (S)-Carnitine hydrochloride, (+)-Carnitine hydrochloride

     D-Carnitine hydrochloride ((S)-Carnitine hydrochloride, (+)-Carnitine hydrochloride) is biosynthesized from lysine. It might be associated with the energy production from branched chain amino acids. D-Carnitine hydrochloride Chemical Structure
  81. GN10072 Daidzin

    Daidzoside, NPI 031D

     Daidzin Chemical Structure
  82. GC47176 Decanoyl-Coenzyme A (hydrate)

    Decanoyl-CoA

     A neuropeptide with diverse biological activities Decanoyl-Coenzyme A (hydrate) Chemical Structure
  83. GC47177 Decanoyl-L-carnitine (hydrate)

    CAR 10:0, C10:0 Carnitine, L-Carnitine decanoyl ester, (-)-Decanoylcarnitine, L-Decanoylcarnitine

     A neuropeptide with diverse biological activities Decanoyl-L-carnitine (hydrate) Chemical Structure
  84. GC47178 Decanoyl-L-carnitine-d3 (chloride)

    CAR 10:0-d3, C10:0 Carnitine-d3, (-)-Decanoylcarnitine-d3, L-Carnitine decanoyl ester-d3, L-Decanoylcarnitine-d3

     A neuropeptide with diverse biological activities Decanoyl-L-carnitine-d3 (chloride) Chemical Structure
  85. GC40538 Decylubiquinone La décylubiquinone est un analogue de l'ubiquinone (coenzyme Q10). Decylubiquinone Chemical Structure
  86. GC18869 Deoxyenterocin

    5-Deoxyenterocin

     Deoxyenterocin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibiotic, antiviral, and antioxidant properties. Deoxyenterocin Chemical Structure
  87. GC49022 Didanosine-d2

    ddl-d2, 2′,3′-Dideoxyinosine-d2

     An internal standard for the quantification of didanosine Didanosine-d2 Chemical Structure
  88. GC38620 Dihydrorotenone

    La dihydroroténone, un pesticide naturel, est un inhibiteur mitochondrial puissant.

     Dihydrorotenone Chemical Structure
  89. GC43463 DiIC1(5) DiIC1(5) is a signal-off fluorescent probe for the detection of mitochondrial membrane potential disruption. DiIC1(5) Chemical Structure
  90. GC47238 Diquat (bromide) Le diquat (bromure) est un herbicide complet couramment utilisé dans la culture du coton, du soja et d'autres cultures pour lutter contre les mauvaises herbes indésirables. Diquat (bromide) Chemical Structure
  91. GC47239 Diquat-d12 (bromide) A neuropeptide with diverse biological activities Diquat-d12 (bromide) Chemical Structure
  92. GC47240 Diquat-d4 (bromide) A neuropeptide with diverse biological activities Diquat-d4 (bromide) Chemical Structure
  93. GC43498 DL-α-Lipoic Acid

    Thioctic Acid

     DL-α-L'acide lipoÏque est un antioxydant, qui est un cofacteur essentiel des complexes enzymatiques mitochondriaux. DL-α-Lipoic Acid Chemical Structure
  94. GC47243 DL-Carnitine-d9 (chloride)

    (±)-Carnitine-d9

     An internal standard for the quantification of carnitine DL-Carnitine-d9 (chloride) Chemical Structure
  95. GC43543 DNP-INT DNP-INT is a quinone analog that inhibits electron transport in plants by competitively inhibiting plastoquinol oxidation by binding at the Qo site of cytochrome b6f (Kd = 1.4 nM). DNP-INT Chemical Structure
  96. GC18439 Doxorubicinone

    Adriamycin aglycone, Adriamycinone, aglycone-DOX, Doxorubicin aglycone, Epirubicin aglycone

     La doxorubicinone est un métabolite d'un agent de chimiothérapie anticancéreux, la doxorubicine. La doxorubicine est un puissant inhibiteur de l'ADN humain de la topoisomérase I et de la topoisomérase II avec des IC50 de 0,8μM et 2,67μM, respectivement. Doxorubicinone Chemical Structure
  97. GC47274 DS44960156 DS44960156 est un inhibiteur sélectif de la méthylènetétrahydrofolate déshydrogénase 2 (MTHFD2), avec des valeurs IC50 de 1,6 μM et> 30 μM pour MTHFD2 et MTHFD1, respectivement . DS44960156 Chemical Structure
  98. GC18992 Duclauxin

    NSC 258308

     Duclauxin decreases proliferation of tumor cells in vitro and increases the lifespan of mice innoculated with Ehrlich ascitic tumor cells. Duclauxin Chemical Structure
  99. GC34569 Elamipretide TFA Elamipretide TFA Chemical Structure
  100. GC72090 Elamipretide triacetate Elamipretide triacetate (MTP - 131 triacétate; RX - 31 triacétate; SS - 31 triacétate) est la forme Elamipretide triacetate de l'elamipletide. Elamipretide triacetate Chemical Structure
  101. GC32858 ER-000444793 ER-000444793 est un puissant inhibiteur de l'ouverture des pores de transition de perméabilité mitochondriale (mPTP). ER-000444793 inhibe mPTP avec une IC50 de 2,8μM. ER-000444793 Chemical Structure

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