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(S)-(-)-5-Fluorowillardiine

Catalog No.GC11889

La (S)-(-)-5-Fluorowillardiine est un agoniste AMPAR puissant et spécifique.

Products are for research use only. Not for human use. We do not sell to patients.

(S)-(-)-5-Fluorowillardiine Chemical Structure

Cas No.: 140187-23-1

Taille Prix Stock Qté
10mg
152,00 $US
Ship Within 7 Days
50mg
585,00 $US
Ship Within 7 Days

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR agonist.

References:
[1]. Hawkinson JE, et al. Effects of thiocyanate and AMPA receptor ligands on (S)-5-fluorowillardiine, (S)-AMPA and (R,S)-AMPA binding. Eur J Pharmacol. 1997 Jun 25;329(2-3):213-21.
[2]. Kessler M, et al. Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators. Brain Res. 2006 Mar 3;1076(1):25-41.
[3]. Rembach A, et al. Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS. J Neurosci Res. 2004 Aug 15;77(4):573-82.

Chemical Properties

Cas No. 140187-23-1 SDF
Chemical Name (S)-2-amino-3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid
Canonical SMILES FC1=CN(C(NC1=O)=O)C[C@@H](C(O)=O)N
Formula C7H8FN3O4 M.Wt 217.16
Solubility Soluble to 50 mM in 1.1eq. NaOH Storage Store at 2-8°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.6049 mL 23.0245 mL 46.049 mL
5 mM 0.921 mL 4.6049 mL 9.2098 mL
10 mM 0.4605 mL 2.3024 mL 4.6049 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for (S)-(-)-5-Fluorowillardiine

Average Rating: 5 ★★★★★ (Based on Reviews and 19 reference(s) in Google Scholar.)

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