V-9302 hydrochloride |
| Catalog No.GC39253 |
Le chlorhydrate de V-9302 est un antagoniste compétitif du flux de glutamine transmembranaire. Le chlorhydrate de V-9302 cible sélectivement et puissamment le transporteur d'acides aminés ASCT2 (SLC1A5) et non ASCT1. Le chlorhydrate de V-9302 inhibe l'absorption de glutamine médiée par ASCT2 (IC50=9,6 uM) dans les cellules HEK-293.
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Cas No.: 2416138-42-4
Sample solution is provided at 25 µL, 10mM.
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V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. V-9302 hydrochloride selectively and potently targets the amino acid transporter ASCT2 (SLC1A5). V-9302 hydrochloride inhibits ASCT2-mediated glutamine uptake (IC50=9.6 µM) in HEK-293 cells[1].
[1]. Schulte ML, et al. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacyin preclinical models. Nat Med. 2018 Feb;24(2):194-202.
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