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Fucosylated Ganglioside GM1 (porcine) (ammonium salt) (Synonyms: Fucosylated Monosialoganglioside GM1, Fucosyl GM1)

Catalog No.GC52483

A sphingolipid

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Fucosylated Ganglioside GM1 (porcine) (ammonium salt) Chemical Structure

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500 μg
$991.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Fucosylated ganglioside GM1 is a fucose-containing glycosphingolipid that was originally found in bovine thyroid tissue.1 It has been found in isolated human small cell lung cancer (SCLC) tumors but is rarely found in other types of lung cancer tumors or normal tissue.2 Fucosylated ganglioside GM1 is shed from SCLC cells in vitro and in vivo in SCLC nude mouse xenograft models and can be detected in human plasma.3 It binds to cholera toxin when expressed in rat C6 glioma cultured cells, increasing intracellular cAMP to similar levels as cells expressing ganglioside GM1 .4 This product contains fucosylated ganglioside GM1 molecular species with primarily C22:0 and C24:0 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1526]

1.Macher, B.A., Pacuszka, T., Mullin, B.R., et al.Isolation and identification of a fucose-containing ganglioside from bovine thyroid glandBiochim. Biophys. Acta588(1)35-43(1979) 2.Vangsted, A.J., and Zeuthen, J.Monoclonal antibodies for diagnosis and potential therapy of small cell lung cancer--the ganglioside antigen fucosyl-GM1Acta. Oncol.32(7-8)845-851(1993) 3.Vangsted, A.J., Clausen, H., Kjeldsen, T.B., et al.Immunochemical detection of a small cell lung cancer-associated ganglioside (FucGM1) antigen in serumCancer Res.51(11)2879-2884(1991) 4.Masserini, M., Freire, E., Calappi, E., et al.Fuc-GM1 ganglioside mimics the receptor function of GM1 for cholera toxinBiochemistry31(8)2422-2426(1992)

Chemical Properties

Cas No. SDF Download SDF
Synonyms Fucosylated Monosialoganglioside GM1, Fucosyl GM1
Canonical SMILES OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@@]2([H])[C@@H]([C@H]([C@H]([C@H](O2)CO)O[C@]3([H])O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O[C@@]4([H])[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)O[C@@]5([H])O[C@H](C)[C@H](O)[C@H](O)[C@H]5O)O)CO)O[C@]6(C([O-])=O)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@@H]([C@H](O)CO)O)O6)O)O[C@H]1OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC([R])=O.[NH4+]
Formula C79H140N3O35 ? NH4 (for stearoyl) M.Wt 1710
Solubility Chloroform:Methanol:Water (2:1:0.1): Soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.5848 mL 2.924 mL 5.848 mL
5 mM 0.117 mL 0.5848 mL 1.1696 mL
10 mM 0.0585 mL 0.2924 mL 0.5848 mL
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