Fumonisin B2-13C34 (Synonyms: FB2) |
| Catalog No.GC47378 |
An internal standard for the quantification of fumonisin B2
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1217481-36-1
Sample solution is provided at 25 µL, 10mM.
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Fumonisin B2-13C34 (FB2-13C34) is intended for use as an internal standard for the quantification of FB2 by GC- or LC-MS. FB2 is a mycotoxin that has been found in F. moniliforme.1 It is cytotoxic against a panel of seven rat hepatoma cell lines (IC50s = 3-50 µg/ml), as well as MDCK cells (IC50 = 2 µg/ml).2 FB2 (125-1,000 µM) is also cytotoxic to primary rat hepatocytes and induces hepatocyte nodule formation, a marker of cancer initiation, in rats when administered at a dose of 1,000 mg/kg for 21 days.3 FB2 has been detected in corn and corn-based foods and livestock feeds.4
1.Gelderblom, W.C.A., Jaskiewicz, K., Marasas, W.F.O., et al.Fumonisins-novel mycotoxins with cancer-promoting activity produced by Fusarium moniliformeAppl. Environ. Microbiol.54(7)1806-1811(1988) 2.Shier, W.T., Abbas, H.K., and Mirocha, C.J.Toxicity of the mycotoxins fumonisins B1 and B2 and Alternaria alternata f. sp. lycopersici toxin (AAL) in cultured mammalian cellsMycopathologia116(2)97-104(1991) 3.Gelderblom, W.C.A., Cawood, M.E., Snyman, S.D., et al.Structure-activity relationships of fumonisins in short-term carcinogenesis and cytotoxicity assaysFood Chem. Toxicol.31(6)407-414(1993) 4.Bullerman, L.B.Occurrence of Fusarium and fumonisins on food grains and in foodsFumonisins in food27-38(1996)
| Cas No. | 1217481-36-1 | SDF | |
| Synonyms | FB2 | ||
| Canonical SMILES | O=[13C](O[13C@@H]([13CH2][13C@H]([13CH2][13CH2][13CH2][13CH2][13CH2][13CH2][13C@H]([13CH2][13C@@H]([13C@H]([13CH3])N)O)O)[13CH3])[13C@@H]([13C@H]([13CH3])[13CH2][13CH2][13CH2][13CH3])O[13C]([13CH2][13C@H]([13C](O)=O)[13CH2][13C](O)=O)=O)[13CH2][13C@H]([13C](O)=O)[13CH2][13C](O)=O | ||
| Formula | [13C]34H59NO14 | M.Wt | 739.6 |
| Solubility | Acetonitrile: soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.3521 mL | 6.7604 mL | 13.5208 mL |
| 5 mM | 0.2704 mL | 1.3521 mL | 2.7042 mL |
| 10 mM | 0.1352 mL | 0.676 mL | 1.3521 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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