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GABAA receptor agent 1

Catalog No.GC60862

GABAA receptor agent 1 is a high affinity ligand for GABAA receptor, with potent anticonvulsant activity.

Products are for research use only. Not for human use. We do not sell to patients.

GABAA receptor agent 1 Chemical Structure

Cas No.: 1571-87-5

Size Price Stock Qty
5mg
$132.00
In stock
10mg
$212.00
In stock
25mg
$423.00
In stock
50mg
$677.00
In stock
100mg
$1,159.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

GABAA receptor agent 1 is a high affinity ligand for GABAA receptor, with potent anticonvulsant activity[1].

GABAA receptor agent 1 (30 mg/kg; intraperitoneal) inhibits the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions in swiss albino rats[1].

[1]. Jain P, et al. Design, synthesis and biological evaluation of some novel benzimidazole derivatives for their potential anticonvulsant activity. Arch Pharm Res. 2010 Jul;33(7):971-80.

Chemical Properties

Cas No. 1571-87-5 SDF
Canonical SMILES O=[N+](C1=CC=C2N=C(C3=CC=C(Cl)C=C3)NC2=C1)[O-]
Formula C13H8ClN3O2 M.Wt 273.67
Solubility DMSO: 83.33 mg/mL (304.49 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.654 mL 18.2702 mL 36.5404 mL
5 mM 0.7308 mL 3.654 mL 7.3081 mL
10 mM 0.3654 mL 1.827 mL 3.654 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 13 reference(s) in Google Scholar.)

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