Ganglioside GM4 (chicken egg) (ammonium salt) (Synonyms: Ganglioside G7, Monosialoganglioside GM4)

Ganglioside G_M4 is a sialic acid-containing glycosphingolipid found primarily in the brain of mammals, particularly in human myelin.¹ Ganglioside G_M4 is also found on epithelial cells in the intestinal tract of the red sea bream where it is an attachment site for Gram-negative Vibrios, the bacteria that causes vibriosis in humans after ingestion of raw or undercooked seafood.² Ganglioside G_M4 species have been found as 11 out of 61 gangliosides detected in an adrenal neuroblastoma tumor.³ Administration of ganglioside G_M4 (80 and 160 µg) prevents development of myelin basic protein-induced experimental autoimmune encephalomyelitis (EAE) in guinea pigs.⁴ This product contains ganglioside G_M4 molecular species with primarily 2-hydroxy C22:0, 2-hydroxy C24:0, and 2-hydroxy C23:0 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1535]

1.Ueno, K., Ando, s., and Yu, R.K.Gangliosides of human, cat, and rabbit spinal cords and cord myelinJ. Lipid Res.19(7)863-871(1978) 2.Chisada, S., Shimizu, K., Kamada, H., et al.Vibrios adhere to epithelial cells in the intestinal tract of red sea bream, Pagrus major, utilizing GM4 as an attachment siteFEMS Microbiol. Lett.341(1)18-26(2013) 3.Robu, A.C., Vukeli?, ?., Schiopu, C., et al.Mass spectrometry of gangliosides in extracranial tumors: Application to adrenal neuroblastomaAnal. Biochem.5091-11(2016) 4.Mullin, B.R., Patrick, D.H., Poore, C.M., et al.Prevention of experimental allergic encephalomyelitis by ganglioside GM4Brain Res.296(1)174-176(1984)