Ganglioside GT1b (bovine) (sodium salt) (Synonyms: Ganglioside G1, Trisialoganglioside GT1b)

Name: Ganglioside GT1b (bovine) (sodium salt)
Brand: GlpBio
SKU: GC52505
Availability: InStock
Rating: 5 (30 reviews)

Catalog No.GC52505

A sphingolipid

Products are for research use only. Not for human use. We do not sell to patients.

Ganglioside GT1b (bovine) (sodium salt) Chemical Structure

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1 mg	$147.00	In stock
5 mg	$543.00	In stock

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Sample solution is provided at 25 µL, 10mM.

GlpBio Products Cited In Reputable Papers

Nature
610.7931 (2022): 366-372

Nature
618, 1017–1023 (2023)

Cell
183.7 (2020): 1867-1883

Cell Research
31, 1291–1307 (2021)

Cell Research
33, 273–287 (2023)

Cell Research
33, 546–561 (2023)

Molecular Cancer
21.1 (2022): 1-17

Molecular Cancer
21.1 (2022): 1-18

Cancer Cell
39 (2021): 1-16

Cell Host Microbe
30.8 (2022): 1124-1138

Cell Host Microbe
31.5 (2023): 766-780

Cell Host Microbe
31.3 (2023): 418-43

Cell Metabolism
34.2 (2022): 240-255

Ann Rheum Dis
82(4): 533-545 (2023)

Cell Mol Immunol
20, 264–276 (2023)

Adv Funct Mater
33.35 (2023): 2214998

Description Chemical Properties Product Documents

Product Documents

Quality Control & SDS

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Purity: >98.00%

Ganglioside G_T1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC₅₀ values of 11, 0.74, and 7.2 μM, respectively.¹ Ganglioside G_T1b-containing liposomes bind to the major coat protein VP1 from Merkel cell polyomavirus (MCPyV), which has been identified in Merkel cell carcinomas, identifying ganglioside G_T1b as a putative MCPyV receptor.² Ganglioside G_T1b decreases production of IL-6, IL-10, IgG, IgM, and IgA in human peripheral blood mononuclear cells (PBMCs) by 31.4, 30.5, 60, 59.5, and 58%, respectively, when used at a concentration of 10 μM.³ This product contains ganglioside G_T1b molecular species with variable fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1558]

1.Schengrund, C.-L., DasGupta, B.R., and Ringler, N.J.Binding of botulinum and tetanus neurotoxins to ganglioside GT1b and derivatives thereofJ. Neurochem.57(3)1024-1032(1991) 2.Erickson, K.D., Garcea, R.L., and Tsai, B.Ganglioside GT1b is a putative host cell receptor for the Merkel cell polyomavirusJ. Virol.83(19)10275-10279(2009) 3.Kanda, N., and Tamaki, K.Ganglioside GT1b suppresses immunoglobulin production by human peripheral blood mononuclear cellsImmunology96(4)628-633(1999)

Cas No.		SDF	Download SDF
Synonyms	Ganglioside G1, Trisialoganglioside GT1b
Canonical SMILES	CCCCCCCCCCCCC/C=C/[C@]([H])([C@](NC(CCCCCCCCCCCCCCCCC)=O)([H])CO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2O)O[C@@]3(C([O-])=O)O[C@H]([C@@H]([C@H](C3)O)NC(C)=O)[C@H](O)[C@H](O[C@@]4(C([O-])=O)O[C@H]([C@@H]([C@H](C4)O)NC(C)=O)[C@H](O)[C@H](O)CO)CO)O[C@H]5[C@@H]([C@H]([C@H]([C@H](O5)CO)O)O[C@@H]6O[C@@H]([C@@H]([C@@H]([C@H]6O)O[C@@]7(C([O-])=O)O[C@H]([C@@H]([C@H](C7)O)NC(C)=O)[C@H](O)[C@H](O)CO)O)CO)NC(C)=O)CO)O)O)O.[Na+].[Na+].[Na+]
Formula	C₉₅H₁₆₂N₅O₄₇ • 3Na (for stearoyl)	M.Wt	2126.3
Solubility	Chloroform:Methanol (2:1): Soluble,Water: micellar aggregates	Storage	-20°C
General tips	Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition	Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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		1 mg	5 mg	10 mg
	1 mM	0.4703 mL	2.3515 mL	4.703 mL
	5 mM	0.0941 mL	0.4703 mL	0.9406 mL
	10 mM	0.047 mL	0.2352 mL	0.4703 mL

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Ganglioside GT1b (bovine) (sodium salt) (Synonyms: Ganglioside G1, Trisialoganglioside GT1b)

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