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(R)-(-)-Rolipram Catalog No.GC34984

Size Price Stock Qty
10mM*1mL in DMSO
$97.00
In stock
10mg
$89.00
In stock
50mg
$324.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 85416-75-7 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C1NC[C@@H](C2=CC=C(OC)C(OC3CCCC3)=C2)C1
Formula C16H21NO3 M.Wt 275.34
Solubility DMSO: ≥ 49 mg/mL (177.96 mM) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

(R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

The increase of cAMP synthesis with the adenylate cyclase activator forskolin or the decrease of cAMP hydrolysis by the phosphodiesterase inhibitors Isobutylmethylxanthine (IBMX) and (R)-(-)-Rolipram (MedChem Express) suppresses caspase-1 cleavage and IL-1β secretion in a dose-dependent manner[1].

[1]. Guo C, et al. Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity. 2016 Oct 18;45(4):944.