4-Chloromethamphetamine (hydrochloride) (Synonyms: 4-CMA, p-CMA, para-CMA, Ro 4-6861)

Methamphetamine is a regulated psychoactive compound that is both neurotoxic and prone to addiction.1,2,3 4-Chloromethamphetamine is a halogenated analog of methamphetamine. In vivo, it is converted to 4-chloroamphetamine , which causes rapid depletion of neurological serotonin within hours after injection.4,5 4-Chloroampetamine is highly and selectively neurotoxic, targeting serotonergic neurons.4,5 This product is intended for forensic and research applications.

References
1. Rothman, R.B., Baumann, M.H., Dersch, C.M., et al. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. Science 39(1), 32-41 (2001).
2. Rothman, R.B., Vu, N., Partilla, J.S., et al. In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates. J. Pharmacol. Exp. Ther. 307(1), 138-145 (2003).
3. Jirovsky, D., Lemr, K., SevcÍk, J., et al. Methamphetamine - properties and analytical methods of enantiomer determination. Forensic Sci. Int. 96(1), 61-70 (1998).
4. Fuller, R.W., Baker, J.C., Perry, K.W., et al. Comparison of 4-chloro-, 4-bromo- and 4-fluoroamphetamine in rats: Drug levels in brain and effects on brain serotonin metabolism. Neuropharmacology 14(10), 739-746 (1975).
5. Harvey, J.A., McMaster, S.E., and Fuller, R.W. Comparison between the neurotoxic and serotonin-depleting effects of various halogenated derivatives of amphetamine in the rat. Journal of Pharmacology and Experimental Therapeutics 202(3), 581-589 (1977).