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Ginsenoside Rg1 (Synonyms: Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1)

Catalog No.GN10544

Ginsenoside Rg1 is one of the main active ingredients of ginseng and a steroidal glycoside with various biological activities. Ginsenoside Rg1 reduces brain Aβ levels and reduces NF-κB nuclear translocation.

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Ginsenoside Rg1 Chemical Structure

Cas No.: 22427-39-0

Size Price Stock Qty
10mM (in 1mL DMSO)
$34.00
In stock
20mg
$42.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Protocol

Cell experiment [1]:

Cell lines

human dental pulp cells

Preparation method

hDPCs were incubated with different concentrations of ginsenoside Rg1 (0.1, 0.5, 2.5, 5, 10 and 20 μmol/L). The effects of ginsenoside Rg1 on the proliferative ability of hDPCs were evaluated by a fibroblast colony forming test, MTT assay and flow cytometry for cell cycle. DPCs were incubated with various concentrations of ginsenoside Rg1 for 1, 3, 5 and 7 days.

Reaction Conditions

0.1, 0.5, 2.5, 5, 10 and 20 μmol/L;1, 3, 5 and 7 days

Applications

Ginsenoside Rg 1 (5 μmol/L) significantly promoted the proliferation and differentiation of human dental pulp cells hDPC. Compared with the control group, ALP activity, DSPP and DMP 1 gene expression were increased in the induction group, ginsenoside Rg 1 group and the two combined groups.

Animal experiment [2]:

Animal models

APP/PS1 mice

Preparation method

According to the concentration-response curves, the mice in the G-Rg1 and G-Rg2 groups were injected intraperitoneally once daily with G-Rg1 and G-Rg2 (30 mg/kg), respectively, dissolved in saline. The mice in the AD model group (APP/PS1 mice) and the normal control group (C57BL/6J nontransgenic littermates) were treated with isodose saline (0.9% w/v). All mice were treated for 1 month before brain metabolite profiling.

Dosage form

30 mg/kg;1 month

Applications

Ginsenoside Rg 1 and ginsenoside Rg 2 treatment (30 mg/kg; 1 month) effectively improved the cognitive function of APP/PS1 mice, and a gradual improvement in brain pathological abnormalities was observed, and the accumulation of Aβ deposits was effectively reduced.

References:

[1] Wang P, et al. Effect of ginsenoside Rg1 on proliferation and differentiation of human dental pulp cells in vitro. Aust Dent J. 2012 Jun;57(2):157-65.

[2] Li N, et al. A UPLC/MS-based metabolomics investigation of the protective effect of ginsenosides Rg1 and Rg2 in mice with Alzheimer's disease. J Ginseng Res. 2016 Jan;40(1):9-17.

Background

Ginsenoside Rg1, one of the main active components found in Panax ginseng, is a class of natural products known as steroid glycosides with a wide range of biological activities. Ginsenoside Rg1 has attracted significant attention due to its various pharmacological effects, including the promotion of hippocampal neurogenesis, improvement of neural plasticity, enhancement of learning and memory, anti-aging and anti-fatigue effects, as well as immunoregulatory and anti-tumor activities. Treatment with G-Rg1 has also been shown to significantly reduce the expression of TNF-α, IL-1β, and IL-6 in ischemia-reperfusion animal and cell models[1]. Ginsenoside Rg1 has been demonstrated to have significant neuroprotective effects, reduce brain levels of Aβ, and decrease NF-κB nuclear translocation, making it a potential therapeutic agent for neurodegenerative diseases such as Alzheimer's and Parkinson's diseases[4].

 

In vitro, ginsenoside Rg1 (5 μmol/L) significantly promoted the proliferation and differentiation of human dental pulp cells (hDPCs). Compared with the control group, the induced group, the ginsenoside Rg1 group, and the combination of both showed increased ALP activity and expressions of DSPP and DMP1 genes[1]. Another study indicated that Rg1 significantly reduced the levels of TNF-α and IL-6 in inflamed joints of AIA rats and LPS-stimulated RAW 264.7 cells, increased PPAR-γ protein expression, and inhibited the phosphorylation of IκBα and the nuclear translocation of NF-κB[2].

 

In vivo, intraperitoneal injection of Rg1 (5, 10, and 20 mg/kg) in AIA rats for 14 consecutive days showed therapeutic effects on arthritis, significantly alleviating joint swelling and damage[2]. Moreover, treatment with ginsenoside Rg1 and Rg2 (30 mg/kg; 1 month) effectively improved the cognitive function of APP/PS1 mice, observed gradual improvement in brain pathological abnormalities, and effectively reduced the accumulation of Aβ deposits[3].

 

References:

[1] Zhang L, et al. Ginsenoside Rg1 attenuates adjuvant-induced arthritis in rats via modulation of PPAR-γ/NF-κB signal pathway. Oncotarget. 2017 Jul 24;8(33):55384-55393.

[2] Wang P, et al. Effect of ginsenoside Rg1 on proliferation and differentiation of human dental pulp cells in vitro. Aust Dent J. 2012 Jun;57(2):157-65.

[3] Li N, et al. A UPLC/MS-based metabolomics investigation of the protective effect of ginsenosides Rg1 and Rg2 in mice with Alzheimer's disease. J Ginseng Res. 2016 Jan;40(1):9-17.

[4] Xie W , Zhou P , Sun Y ,et al. Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies[J].Cells, 2018, 7(12).

Chemical Properties

Cas No. 22427-39-0 SDF
Synonyms Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1
Chemical Name Ginsenoside Rg1
Canonical SMILES CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)OC5C(C(C(C(O5)CO)O)O)O)C)O)C)OC6C(C(C(C(O6)CO)O)O)O)C
Formula C42H72O14 M.Wt 801.01
Solubility ≥ 32mg/mL in DMSO Storage Store at 4°C Keep from the light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.2484 mL 6.2421 mL 12.4842 mL
5 mM 0.2497 mL 1.2484 mL 2.4968 mL
10 mM 0.1248 mL 0.6242 mL 1.2484 mL
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