Glaucine (Synonyms: Boldine Dimethyl Ether, (+)-Glaucine, NSC 34396, 1,2,9,10-Tetramethoxyaporphine) |
| Catalog No.GC41486 |
Glaucine is an alkaloid originally isolated from G.
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Cas No.: 475-81-0
Sample solution is provided at 25 µL, 10mM.
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Glaucine is an alkaloid originally isolated from G. flavum that demonstrates antitussive properties. It is structurally related to papaverine , a non-selective phosphodiesterase (PDE) inhibitor. Glaucine selectively inhibits PDE4 (Kis = 3.4 µM in human bronchus and polymorphonuclear leukocytes). It has been shown to have bronchodilation and anti-inflammatory effects, inhibiting the spontaneous and histamine-induced tone in human isolated bronchus and augmenting cyclic AMP accumulation. Glaucine also binds to the benzothiazepine site on L-type Ca2+-channels in smooth muscle, blocking calcium ion signaling. This compound has been detected as a recreational drug capable of eliciting dissociative effects.
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