Globotriaosylceramide (hydroxy) (porcine RBC) (Synonyms: Ceramide Trihexosides (bottom spot) (porcine)) |
Catalog No.GC52492 |
A sphingolipid
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Globotriaosycleramides are glycosphingolipids found in mammalian cell membranes that are synthesized from lactosylceramides .1 They act as receptors for Shiga and Shiga-like toxins in vitro and in vivo.2 Globotriaosylceramides accumulate in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A.3 Globotriaosylceramides act as natural resistance factors to HIV infection, interacting with HIV gp120 to prevent its interaction with chemokine co-receptors and subsequent fusion of HIV to host cell membranes.1 This product contains hydroxy fatty acid-containing globotriaosylceramide molecular species with primarily 2-hydroxy C24:0 and 2-hydroxy C24:1 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1514]
1.Lingwood, C.A., and Branch, D.R.The role of glycosphingolipids in HIV/AIDSDiscov. Med.11(59)303-313(2011) 2.Takeda, Y., Kurazono, H., and Yamasaki, S.Vero toxins (Shiga-like toxins) produced by enterohemorrhagic Escherichia coli (verocytotoxin-producing E. coli)Microbiol. Immunol.37(8)591-599(1993) 3.Feldt-Rasmussen, U., Rasmussen, A.K., Mersebach, H., et al.Fabry disease: A new challenge in endocrinology and metabolism•Eur. J. Endocrinol.146(6)741-742(2002)
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(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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