Glucagon receptor antagonists-4 (Synonyms: GCGR Antagonist IV) |
| Catalog No.GC19170 |
Glucagon receptor antagonists-4 is a highly potent, non-peptide and orally active glucagon receptor antagonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1393124-08-7
Sample solution is provided at 25 µL, 10mM.
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Glucagon receptor antagonists-4 is a highly potent glucagon receptor antagonist. It displays low in vivo clearance and excellent oral bioavailability in both rats and dogs.
References:
[1]. Guzman-Perez A et al. The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical andpharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus. Bioorg Med Chem Lett, 2013 May 15, 23(10):3051-8.
[2]. Esther C.Y. Lee et al. Identification of a novel conformationally constrained glucagon receptor antagonist. Bioorg Med Chem Lett, 2014 Feb 1, 24(3):839-44.
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