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Glucosylceramide (bovine buttermilk) (Synonyms: GluCers (buttermilk), Glucocerebrosides (buttermilk))

Catalog No.GC52493

A sphingolipid

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Glucosylceramide (bovine buttermilk) Chemical Structure

Size Price Stock Qty
500 μg
$85.00
In stock
1 mg
$160.00
In stock
5 mg
$333.00
In stock
50 mg
$2,495.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Glucosylceramides are formed by the tethering of glucose to a ceramide by glucosylceramides synthase.1 They are present in neuronal and non-neuronal mammalian tissues and are found at low quantities in a large number of plant species, where they comprise 5-30% of total lipids in the plant plasma membrane, and in fungi.1,2,3 Glucosylceramides levels decrease during cold acclimatization in plants and glucosylceramides in fungi are involved in the regulation of virulence and act as elicitors in plants, stimulating plant defense mechanisms.3,4 Glucosylceramides are precursors in the synthesis of lactosylceramides and gangliosides. Increased levels of glucosylceramides are associated with obesity-induced insulin resistance in mice and with neuronal deficits observed in neuronopathic Gaucher disease.1,5 This product contains glucosylceramide molecular species with primarily C22:0, C23:0, and C24:0 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1521]

1.Holland, W.L., and Summers, S.A.Sphingolipids, insulin resistance, and metabolic disease: New insights from in vivo manipulation of sphingolipid metabolismEndocr. Rev.29(4)381-402(2008) 2.Cahoon, E.B., and Lynch, D.V.Analysis of glucocerebrosides of rye (Secale cereale L. cv Puma) leaf and plasma membranePlant Physiol.95(1)56-68(1991) 3.Lynch, D.V., and Dunn, T.M.An introduction to plant sphingolipids and a review of recent advances in understanding their metabolism and functionNew Phytol.161(3)667-702(2004) 4.Rollin-Pinheiro, R., Bernardino, M.C., and Barreto-Bergter, E.Sphingolipids: Functional and biological aspects in mammals, plants, and fungiAnalysis of membrane lipids21-40(2020) 5.Dai, M., Liou, B., Swope, B., et al.Progression of behavioral and CNS deficits in a viable murine model of chronic neuronopathic Gaucher diseasePLoS One11(9)e0162367(2016)

Chemical Properties

Cas No. SDF Download SDF
Synonyms GluCers (buttermilk), Glucocerebrosides (buttermilk)
Canonical SMILES O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC([R])=O)[C@@H]1O
Formula C46H89NO8 (for docosanoyl) M.Wt 784.2
Solubility Chloroform:Methanol (2:1): Soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.2752 mL 6.3759 mL 12.7518 mL
5 mM 0.255 mL 1.2752 mL 2.5504 mL
10 mM 0.1275 mL 0.6376 mL 1.2752 mL
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Reviews

Review for Glucosylceramide (bovine buttermilk)

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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