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GSK-LSD1 Dihydrochloride Catalog No.GC32764

Size Price Stock Qty
10mM*1mLinDMSO
$79.00
In stock
5mg
$71.00
In stock
10mg
$107.00
In stock
25mg
$214.00
In stock
50mg
$375.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Chemical Properties

Cas No. 2102933-95-7 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES C1(N[C@H]2[C@H](C3=CC=CC=C3)C2)CCNCC1.Cl.Cl
Formula C14H22Cl2N2 M.Wt 289.24
Solubility DMSO : ≥ 62.5 mg/mL (216.08 mM) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

GSK-LSD1 Dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM.

GSK-LSD1 Dihydrochloride shows more than 1000 fold selectivity over other closely related FAD utilizing enzymes including LSD2, and monoamine oxidases MAO-A, MAO-B[1]. GSK-LSD1 can inhibit KDM1A/LSD1 enzyme activity. GSK-LSD1 induces the formation of LC3-II in U2OS cells. The electronic microscopy shows the formation of autophagosome with GSK-LSD1 treatment. GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns[2].

[1]. Purich D. The Inhibitor Index A Desk Reference on Enzyme Inhibitors, Receptor Antagonists, Drugs, Toxins, Poisons, Biologics, and Therapeutic Leads. ISBN 9781138739215 [2]. Wang Z, et al. Inhibition of H3K4 demethylation induces autophagy in cancer cell lines. Biochim Biophys Acta. 2017 Aug 8;1864(12):2428-2437.