GSK199 (hydrochloride) |
| Catalog No.GC43789 |
GSK199 (hydrochloride) is a reversible and selective PAD4 inhibitor with an IC50 of 200 nM in the absence of calcium.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1549811-53-1
Sample solution is provided at 25 µL, 10mM.
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Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline. Citrullination of proteins has normal roles in gene regulation and pathological roles in immunological and inflammatory diseases. GSK199 is a reversible inhibitor of PAD4 (IC50 = 200 nM) that binds to the low-calcium form of the enzyme and is selective for PAD4 over PAD1-3.It is less potent than the related PAD4 inhibitor GSK484 , which demonstrates an IC50 value of 50 nM. GSK199 can inhibit the citrullination of PAD4 target proteins and diminish the formation of neutrophil extracellular traps in mouse neutrophils.
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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