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α-Guanidinoglutaric Acid Catalog No.GC11323

linear mixed-type inhibitor of nNOS

Size Price Stock Qty
5mg
$26.00
In stock
10mg
$49.00
In stock
50mg
$208.00
In stock
100mg
$364.00
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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 73477-53-9 SDF
Synonyms GGA
Chemical Name N-(aminoiminomethyl)-L-glutamic acid
Canonical SMILES NC(=N)N[C@@H](CCC(=O)O)C(=O)O
Formula C6H11N3O4 M.Wt 189.2
Solubility ≤50mg/ml in aqueous solutions Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

α-Guanidinoglutaric Acid is a novel nitric oxide synthase inhibitor with Ki value of 2.69 μM [1].

In the brain, nitric oxide (NO), which is synthesized from L-arginine (Arg) by NO synthase (NOS), acts as both an intra- and an intercellular second messenger, and it may suppress convulsions [1].

α-Guanidinoglutaric Acid (GGA) is a novel nitric oxide synthase inhibitor. GGA was increased in the cobalt-induced epileptic focus tissue in the cerebral cortex of cats [2]. GGA is an endogenous, potent, and non-guanidino nitrogen-substituted NOS inhibitor and that inhibition of nitric oxide biosynthesis may be involved in GGA-induced convulsions. In the cobalt-induced epileptic focus, GGA might inhibit NO production. GGA is a useful tool for the study of the enzyme-substrate relationship of NOS [1].

In rats, GGA injected in the cerebroventricle caused sporadic spike discharges with a latency of several minutes. When Arg was supplemented with GGA, no sporadic spike discharges were observed. These results indicated that Arg elevated the threshold of GGA-induced seizures. The initiation of the seizures induced by GGA was associated with a decrease in the 5-hydroxytryptamine level [1].

References:
[1].  Yokoi I, Kabuto H, Habu H, Mori A. alpha-Guanidinoglutaric acid, an endogenous convulsant, as a novel nitric oxide synthase inhibitor. J Neurochem. 1994 Oct;63(4):1565-7.
[2].  Mori A, Akagi M, Katayama Y, et al. alpha-Guanidinoglutaric acid in cobalt-induced epileptogenic cerebral cortex of cats. J Neurochem. 1980 Sep;35(3):603-5.