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Helioxanthin 8-1

Catalog No.GC13722

inhibitor of HBV and HIV virus

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Helioxanthin 8-1 Chemical Structure

Cas No.: 840529-13-7

Size Price Stock Qty
10mM (in 1mL DMSO)
$261.00
In stock
2mg
$210.00
In stock
5mg
$315.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Helioxanthin 8-1, an analogue of helioxanthin (ACH126447), is an inhibitor of HBV and HIV virus with EC50 values of 0.03 μM and 2.7 μM, respectively [1].

Helioxanthin 8-1 is the cyclic hydrazide derivative of helioxanthin and has shown significant in vitro antivirus activity with EC50 values of 0.03 μM and 2.7 μM for HBV and HIV, respectively [1]. In the ds-tet5 cells, helioxanthin 8-1 can inhibit duck hepatitis B virus (DHBV) DNA synthesis with a mean IC50 value of 0.25±0.05 μM. Besides, in induced cells and non-induced ds-tet5 cells, helioxanthin 8-1 has cytotoxic effect with CC50 values of 18±2 μM and 45±3 μM, respectively, by using an MTT assay [2].

References:
[1] Yeo H1, Li Y, Fu L, Zhu JL, Gullen EA, Dutschman GE, Lee Y, Chung R, Huang ES, Austin DJ, Cheng YC. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46.
[2] Ying C1, Tan S, Cheng YC.  Helioxanthin analogue 8-1 inhibits duck hepatitis B virus replication in cell culture. Antivir Chem Chemother. 2010;21(2):97-103.

Chemical Properties

Cas No. 840529-13-7 SDF
Chemical Name 11-(benzo[d][1,3]dioxol-5-yl)-[1,3]dioxolo[4',5':3,4]benzo[1,2-g]phthalazine-7,10-diol
Canonical SMILES OC1=NN=C(O)C2=C1C=C3C=CC(OCO4)=C4C3=C2C5=CC6=C(OCO6)C=C5
Formula C20H12N2O6 M.Wt 376.32
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.6573 mL 13.2866 mL 26.5731 mL
5 mM 0.5315 mL 2.6573 mL 5.3146 mL
10 mM 0.2657 mL 1.3287 mL 2.6573 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 35 reference(s) in Google Scholar.)

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