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Hemokinin 1 (human) (trifluoroacetate salt) (Synonyms: HK-1, TGKASQFFGLM-NH2, Thr-Gly-Lys-Ala-Ser-Gln-Phe-Phe-Gly-Leu-Met-NH2)

Catalog No.GC49882

A peptide agonist of NK1 receptors

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Hemokinin 1 (human) (trifluoroacetate salt) Chemical Structure

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1 mg
$394.00
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5 mg
$1,778.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Hemokinin 1 is a tachykinin peptide neurokinin-1 (NK1) receptor agonist.1,2,3,4,5 It induces migration of A375 and B16/F10 melanoma cells when used at a concentration of 1 µM, an effect that can be reversed by the NK1 receptor antagonist L-732,138 .1 Hemokinin 1 (0.001-0.1 µM) promotes the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs).2 It induces the production of prostaglandin E2 in human colon mucosal and muscle explants.3 Intracerebroventricular administration of hemokinin 1 increases the latency to withdrawal in the tail-flick test in mice in a dose-dependent manner.4 It decreases mean arterial pressure (MAP) and heart rate in anesthetized rats when administered at doses ranging from 1 to 30 nmol/kg.5

1.Zhang, Y., Li, X., Li, J., et al.Human hemokinin-1 promotes migration of melanoma cells and increases MMP-2 and MT1-MMP expression by activating tumor cell NK1 receptorsPeptides838-15(2016) 2.Song, H., Yin, W., Zeng, Q., et al.Hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptorInt. J. Biochem. Cell Biol.44(9)1410-1421(2012) 3.Dai, L., Perera, D.S., King, D.W., et al.Hemokinin-1 stimulates prostaglandin E2 production in human colon through activation of cyclooxygenase-2 and inhibition of 15-hydroxyprostaglandin dehydrogenaseJ. Pharmacol. Exp. Ther.340(1)27-36(2012) 4.Fu, C.Y., Zhao, Y.L., Dong, L., et al.In vivo characterization of the effects of human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, on the modulation of pain in miceBrain Behav. Immun.22(6)850-860(2008) 5.Kong, Z.-Q., Fu, C.-Y., Chen, Q., et al.Cardiovascular responses to intravenous administration of human hemokinin-1 and its truncated form hemokinin-1(4-11) in anesthetized ratsEur. J. Pharmacol.590(1-3)310-316(2008)

Chemical Properties

Cas No. SDF Download SDF
Synonyms HK-1, TGKASQFFGLM-NH2, Thr-Gly-Lys-Ala-Ser-Gln-Phe-Phe-Gly-Leu-Met-NH2
Canonical SMILES CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC(CNC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@H](C)NC([C@H](CCCCN)NC(CNC([C@@H](N)[C@H](O)C)=O)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O.OC(C(F)(F)F)=O
Formula C54H84N14O14S • XCF3COOH M.Wt 1185.4
Solubility Water: soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.8436 mL 4.218 mL 8.436 mL
5 mM 0.1687 mL 0.8436 mL 1.6872 mL
10 mM 0.0844 mL 0.4218 mL 0.8436 mL
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Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 15 reference(s) in Google Scholar.)

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