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Hexadecyl Methyl Glycerol (Synonyms: 1-O-hexadecyl-2-O-methyl-sn-Glycerol)

Catalog No.GC10299

protein kinase C activity inhibitor

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Hexadecyl Methyl Glycerol Chemical Structure

Cas No.: 96960-92-8

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10mg
$44.00
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50mg
$88.00
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100mg
$151.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Hexadecyl Methyl Glycerol, also known as AMG-C16 with a hexadecyl chain at the sn-1 position, is a novel inhibitor of protein kinase C with IC50 value of about 80 μM [1].

Protein kinase C is a phospholipid-dependent kinase and the intracellular receptor for phorbol 12-myristate-13-acetate (PMA), a substance that activates both the respiratory burst and protein kinase C. PKC enzymes are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+) [1].

Hexadecyl Methyl Glycerol is a structural analog of diacylglycerol with a hexadecyl chain at the sn-1 position and a methyl group at the sn-2 position. Hexadecyl Methyl Glycerol inhibited the activation of purified protein kinase C by diacylglycerol in the presence of phosphatidylserine. In neutrophilic granulocytes, Hexadecyl Methyl Glycerol inhibited the respiratory burst induced by PDBu in a dose-dependent way. In neutrophils, Hexadecyl Methyl Glycerol inhibited the phosphorylation of purified 47-kDa protein, an important substrate of protein kinase C [1].

Reference:
[1].  Kramer IM1, van der Bend RL, Tool AT, et al. 1-O-hexadecyl-2-Q-methylglycerol, a novel inhibitor of protein kinase C, inhibits the respiratory burst in human neutrophils. J Biol Chem. 1989 Apr 5;264(10):5876-84.

Chemical Properties

Cas No. 96960-92-8 SDF
Synonyms 1-O-hexadecyl-2-O-methyl-sn-Glycerol
Chemical Name 1-O-hexadecyl-2-O-methyl-sn-glycerol
Canonical SMILES CCCCCCCCCCCCCCCCOCC(CO)OC
Formula C20H42O3 M.Wt 330.6
Solubility ≤8.3mg/ml in DMSO;8.3mg/ml in dimethyl formamide Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.0248 mL 15.124 mL 30.248 mL
5 mM 0.605 mL 3.0248 mL 6.0496 mL
10 mM 0.3025 mL 1.5124 mL 3.0248 mL
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