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Histone-H2A-(107-122)-Ac-OH

Catalog No.GP10020

Histone-H2A-(107-122)-Ac-OH Chemical Structure

Histone-H2A peptide

Size Price Stock Qty
1mg
$57.00
In stock
5mg
$158.00
In stock
10mg
$265.00
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25mg
$405.00
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Sample solution is provided at 25 µL, 10mM.

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Background

Histone-H2A-(107-122)-Ac-OH, (C81H140N20O23), a peptide with the sequence Ac-Gly-Val-Leu-Pro-Asn-Ile-Gln-Ala-Val-Leu-Leu-Pro-Lys-Lys-Thr-Glu-OH, MW= 1762.1. Histone H2Ais one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Histones are proteins that package DNA into nucleosomes1. Histones are responsible for maintaining the shape and structure of a nucleosome. One chromatin molecule is composed of at least one of each core histones per 100 base pairs of DNA. There are five families of histones known to date; these histones are termed H1/H5, H2A, H2B, H3, and H42.H2A is important for packaging DNA into chromatin. Since H2A packages DNA molecules into chromatin, the packaging process will effect gene expression.H2A has been correlated with DNA modification and epigenetics. H2A plays a major role in determining the overall structure of chromatin. Inadvertently, H2A has been found to regulate gene expression3. DNA modification by H2A occurs in the cell nucleus. Proteins responsible for nuclear import of H2A protein are karyopherin and importin. Recent studies also show that nucleosome assembly protein 1 is also used to transport of H2A into the nucleus so it can wrap DNA. Other functions of H2A have been seen in the histone variant H2A.Z. This variant is associated with gene activation, silencing and suppression of antisense RNA. In addition, when H2A.Z was studied in human and yeast cells, it was used to promote RNA polymerase II recruitment4.

References:
1. Youngson, Robert M. (2006).Collins Dictionary of Human Biology.Glasgow: HarperCollins.
2. Khorasanizadeh, Sepideh. 2004. The Nucleosome: From Genomic Organization to Genomic Regulation. Department of Biochemistry and Molecular Genetics,UniversityofVirginia HealthSystem. Cellular Biology. Volume 116, Issue 2, , Pages 259-272.
3. Marino-Ramirez L, Jordan IK, Landsman D. Multiple independent evolutionary solutions to core histone gene regulation. Genome Biol. 2006;7:R12
4. Marino-Ramirez L, Levine KM, Morales M, Zhang S, Moreland. RT, Baxevanis AD, Landsman D (2011) The histone database: an integrated resource for histones and histone fold-containing proteins. Database (Oxford) bar048

Chemical Properties

Cas No. N/A SDF
Synonyms Ac-Gly-Val-Leu-Pro-Asn-Ile-Gln-Ala-Val-Leu-Leu-Pro-Lys-Lys-Thr-Glu-OH
Chemical Name N/A
Canonical SMILES CC(NCC(NC(C(C)C)C(NC(CC(C)C)C(N1C(C(NC(CC(N)=O)C(NC(C(CC)C)C(NC(CCC(N)=O)C(NC(C)C(NC(C(NC(CC(C)C)C(NC(CC(C)C)C(N2C(C(NC(CCCCN)C(NC(CCCCN)C(NC(C(C)O)C(NC(C(O)=O)CCC(O)=O)=O)=O)=O)=O)CCC2)=O)=O)=O)C(C)C)=O)=O)=O)=O)=O)CCC1)=O)=O)=O)=O
Formula C81H140N20O23 M.Wt 1762.1
Solubility ≥ 176.2mg/mL in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Review for Histone-H2A-(107-122)-Ac-OH

Average Rating: 5 ★★★★★ (Based on Reviews and 6 reference(s) in Google Scholar.)

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