Hydrochlorothiazide Impurity C |
| Catalog No.GC43872 |
Hydrochlorothiazide impurity C is a potential impurity found in commercial hydrochlorothiazide preparations.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 402824-96-8
Sample solution is provided at 25 µL, 10mM.
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Hydrochlorothiazide impurity C is a potential impurity found in commercial hydrochlorothiazide preparations. [1] Hydrochlorothiazide is a thiazide diuretic that inhibits the apical membrane sodium chloride cotransporter in the distal and collecting duct nephron segments.[2][3][4]
Reference:
[1]. Fang, X., Bibart, R.T., Mayr, S., et al. Purification and identification of an impurity in bulk hydrochlorothiazide. J. Pharm. Sci. 90(11), 1800-1809 (2001).
[2]. Odlind, B., and Lönnerholm, G. Renal tubular secretion and effects of chlorothiazide, hydrochlorothiazide and clopamide: A study in the avian kidney. Acta.Pharmacol.Toxicol (Copenh) 51(3), 187-197 (1982).
[3]. Majid, D.S.A., and Navar, L.G. Blockade of distal nephron sodium transport attenuates pressure natriuresis in dogs. Hypertension 23(6 Pt 2), 1040-1045 (1994).
[4]. Vongpatanasin, W. Hydrochlorothiazide (HCTZ) is not the most useful nor versatile thiazide diuretic. Curr. Opin. Cardiol. 30(4), 361-365 (2015).
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