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I-BET 151 dihydrochloride (Synonyms: GSK1210151A dihydrochloride)

Catalog No.GC50070

BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes

Products are for research use only. Not for human use. We do not sell to patients.

I-BET 151 dihydrochloride Chemical Structure

Cas No.: 1883545-47-8

Size Price Stock Qty
10 mg
$397.00
In stock
50 mg
$1,626.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

BET bromodomain inhibitor; blocks recruitment of BET to chromatin. Induces apoptosis and G0/G1 cell cycle arrest in MLL-fusion leukemic cell lines in vitro (IC50 values are 15, 26, 120 and 192 nM for NOMO1, MV4;11, MOLM13 and RS4;11 cell lines respectively); reduces BCL2 expression in NOMO1 cells. Improves survival in two rodent models of MLL-fusion leukemia in vivo. Enhances differentiation of human iPSC into megakaryocytes. Also enhances fibroblast reprogramming to hiPSCs at low concentration.

Dawson et al (2011) Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 478 529 PMID:21964340 |Feng et al (2014) Scalable generation of universal platelets from human induced pluripotent stem cells. Stem Cell Reports 3 817 PMID:25418726 |Shao et al (2016) Reprogramming by de-bookmarking the somatic transcriptional program through targeting of BET bromodomains. Cell Rep. 16 3138 PMID:27653680

Chemical Properties

Cas No. 1883545-47-8 SDF
Synonyms GSK1210151A dihydrochloride
Canonical SMILES O=C(N3[C@H](C)C4=NC=CC=C4)NC2=C3C1=CC(OC)=C(C5=C(C)ON=C5C)C=C1N=C2.Cl.Cl
Formula C23H21N5O3.2HCl M.Wt 488.37
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.0476 mL 10.2381 mL 20.4763 mL
5 mM 0.4095 mL 2.0476 mL 4.0953 mL
10 mM 0.2048 mL 1.0238 mL 2.0476 mL
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Review for I-BET 151 dihydrochloride

Average Rating: 5 ★★★★★ (Based on Reviews and 14 reference(s) in Google Scholar.)

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