IKKε-IN-1 |
| Catalog No.GC13278 |
potent IKKε inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1292310-49-6
Sample solution is provided at 25 µL, 10mM.
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TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.
TBK1/IKKε-IN-2 (Cmpound #1) inhibits TBK1 biochemical function in Ulight kinase assay at 5 and 250 μM ATP concentration with IC50s of 0.6 and 2.6 nM, rsespectively. TBK1/IKKε-IN-2 inhibits IKKε biochemical function in Ulight kinase assay at 10 μM ATP with an IC50 of 3.9 nM. The IC50 of TBK1/IKKε-IN-2 in the Panc 02.13 proliferation assay is 5 μM[1].
References:
[1]. Muvaffak A, et al. Evaluating TBK1 as a therapeutic target in cancers with activated IRF3. Mol Cancer Res. 2014 Jul;12(7):1055-66.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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