IL-1R Antagonist |
| Catalog No.GC18529 |
IL-1R Antagonist (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 566914-00-9
Sample solution is provided at 25 µL, 10mM.
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IL-1R antagonist is a peptide mimic of the myeloid differentiation primary response gene 88 (MyD88) that changes the interaction of MyD88 and IL-1 receptor type I (IL-1RI). In mouse lymphocytes and thymoma EL4 cells, IL-1R antagonist (>=10 μM) inhibits IL-1β-activated phosphorylation of p38 MAP kinase, a process specifically mediated by disruption of IL-1RI/MyD88. However, it has no influence on LPS-mediated TLR4/MyD88 signaling in freshly isolated mouse lymphocytes (100 μM). IL-1R antagonist also attenuates IL-1β-induced fever (200 mg/kg) and Staphylococcal enterotoxin B (SEB)-induced pro-inflammatory cytokine production and toxicity in mice at doses between 2-6 mg.[1]
Reference:
[1]. Bartfai, T., Behrens, M.M., Gaidarova, S., et al. A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Proc. Natl. Acad. Sci. USA 100(13), 7971-7976 (2003).
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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