Indole-3-pyruvic Acid (Synonyms: Indole-3-pyruvate, IPA, IPyr, NSC 88874) |
| Catalog No.GC47456 |
Indole-3-pyruvic Acid, a keto analogue of tryptophan, is an orally active AHR agonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 392-12-1
Sample solution is provided at 25 µL, 10mM.
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Indole-3-pyruvic acid is an endogenous metabolite of tryptophan and intermediate in the biosynthesis of the major auxin hormone, indole-3-acetic acid , in plants.[1][2][3] Indole-3-pyruvic acid (50 and 250 µM) activates the aryl hydrocarbon receptor (AhR) in a reporter assay.[1] It reduces UVB-induced cytotoxicity and the levels of COX-2 in HaCaT keratinocytes.4 Topical administration of indole-3-pyruvic acid (100 µmol) reduces the severity of UVB-induced damage in mouse skin. Dietary administration of indole-3-pyruvic acid (0.1%) reduces diarrhea, colonic inflammation, and the colonic expression of Il1b, Ifng, Tnfa, and Il12b in a mouse model of T cell-mediated colitis.[1] It increases the time spent in the open arms of the elevated plus maze in mice when administered at a dose of 100 mg/kg.[2] It also reverses the anxiogenic effect of caffeine and 3-hydroxy kynurenine, but not pentylenetetrazole or phenylethylamine, in the elevated plus maze in mice.
Reference:
[1].Aoki, R., Aoki-Yoshida, A., Suzuki, C., et al.Indole-3-pyruvic acid, an aryl hydrocarbon receptor activator, suppresses experimental colitis in miceJ. Immunol.201(12)3683-3693(2018)
[2].Lapin, I.P., and Politi, V.Anxiolytic effect of indole-3-pyruvic acid (IPA) in micePharmacol. Res.28(2)129-134(1993)
[3].Mashiguchi, K., Tanaka, K., Sakai, T., et al.The main auxin biosynthesis pathway in ArabidopsisProc. Natl. Acad. Sci. USA108(45)18512-18517(2011)
[4].Aoki, R., Aoki-Yoshida, A., Suzuki, C., et al.Protective effect of indole-3-pyruvate against ultraviolet b-induced damage to cultured HaCaT keratinocytes and the skin of hairless micePLoS One9(5)e96804(2014)
| Cas No. | 392-12-1 | SDF | |
| Synonyms | Indole-3-pyruvate, IPA, IPyr, NSC 88874 | ||
| Canonical SMILES | O=C(C(O)=O)CC1=CNC2=CC=CC=C21 | ||
| Formula | C11H9NO3 | M.Wt | 203.2 |
| Solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.9213 mL | 24.6063 mL | 49.2126 mL |
| 5 mM | 0.9843 mL | 4.9213 mL | 9.8425 mL |
| 10 mM | 0.4921 mL | 2.4606 mL | 4.9213 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)
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