Infliximab

Infliximab is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research^[1][2]. So, infliximab is a medication used to treat patients with autoimmune and chronic inflammatory diseases^[5].

infliximab has been also shown to improve insulin resistance^[3]. In vitro,infliximab ameliorates TNF-alpha-induced insulin resistance in 3T3L1 adipocytes in vitro by restoring phosphorylation of key mediators of the insulin signaling pathway such as IRS-2 and AKT via PTP1B inhibition that in consequence improves insulin-dependent glucose uptake in these adipose cells^[4]

Diabetic mice showed significant impairments in SNCV and MNCV at 8 weeks. Diabetic mice treated with saline showed no improvement in SNCV or MNCV at 12 weeks, whereas diabetic mice treated with infliximab showed significant improvement at this time (4 weeks after infliximab treatment). In conclusion a single injection of infliximab leads to marked improvement in diabetic neuropathy^[7].Infliximab reduces the levels of serum insulin, fasting glucose and insulin resistance in patients with ankylosing spondylitis and rheumatoid arthritis^[6]

References:
[1]. Lis K, Kuzawińska O, et,al. Tumor necrosis factor inhibitors - state of knowledge. Arch Med Sci. 2014 Dec 22;10(6):1175-85. doi: 10.5114/aoms.2014.47827. PMID: 25624856; PMCID: PMC4296073.
[2]. Yamakawa I, Kojima H, Terashima T, et,al.Inactivation of TNF-α ameliorates diabetic neuropathy in mice. Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E844-52. doi: 10.1152/ajpendo.00029.2011. Epub 2011 Aug 2. PMID: 21810933; PMCID: PMC3213998.
[3]. Burska AN, Sakthiswary R, et,al. Effects of Tumour Necrosis Factor Antagonists on Insulin Sensitivity/Resistance in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. PLoS One. 2015 Jun 25;10(6):e0128889. doi: 10.1371/journal.pone.0128889. PMID: 26110878; PMCID: PMC4482317.
[4]. Méndez-García LA, Trejo-Millán F, et,al.Infliximab ameliorates tumor necrosis factor-alpha-induced insulin resistance by attenuating PTP1B activation in 3T3L1 adipocytes in vitro. Scand J Immunol. 2018 Nov;88(5):e12716. doi: 10.1111/sji.12716. Epub 2018 Oct 10. PMID: 30260514.
[5]. Antoni C, Krueger GG, et,al. Infliximab improves signs and symptoms of psoriatic arthritis: results of the IMPACT 2 trial. Ann Rheum Dis. 2005 Aug;64(8):1150-7. doi: 10.1136/ard.2004.032268. Epub 2005 Jan 27. PMID: 15677701; PMCID: PMC1755609.
[6]. Stagakis I, Bertsias G, et,al.Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance. Arthritis Res Ther. 2012 Jun 12;14(3):R141. doi: 10.1186/ar3874. PMID: 22691241; PMCID: PMC3446524.
[7]. Yamakawa I, Kojima H, et,al.Inactivation of TNF-α ameliorates diabetic neuropathy in mice. Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E844-52. doi: 10.1152/ajpendo.00029.2011. Epub 2011 Aug 2. PMID: 21810933; PMCID: PMC3213998.