INH14 |
| Catalog No.GC34907 |
INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 200134-22-1
Sample solution is provided at 25 µL, 10mM.
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INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14 inhibits the IKKα/β-dependent TLR inflammatory response. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity[1]. IKKβ|3.59 μM (IC50)|IKKα|8.97 μM (IC50)
INH14 (5 µg/g, i.p. for 2 hours) reduces lipopeptide-induced inflammation in mice[1]. Animal Model: 8-week old, male, pathogen-free C57BL/6J mice[1]
[1]. Drexel M, et al. INH14, a Small-Molecule Urea Derivative, Inhibits the IKKα/β-Dependent TLR Inflammatory Response. Chembiochem. 2019 Mar 1;20(5):710-717.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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