IRL 1620 (trifluoroacetate salt) (Synonyms: PMZ-1620, SPI 1620, Suc-Glu9, Ala11,15-ET-1(8-21))

Name: IRL 1620 (trifluoroacetate salt)
Brand: GlpBio
SKU: GC49493
Availability: InStock
Rating: 5 (24 reviews)

Catalog No.GC49493

A peptide ET_B receptor agonist

Products are for research use only. Not for human use. We do not sell to patients.

IRL 1620 (trifluoroacetate salt) Chemical Structure

Cas No.: N/A

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500 µg	$136.00	In stock
1 mg	$217.00	In stock
5 mg	$814.00	In stock

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Sample solution is provided at 25 µL, 10mM.

GlpBio Products Cited In Reputable Papers

Nature
610.7931 (2022): 366-372

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183.7 (2020): 1867-1883

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33, 273–287 (2023)

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Molecular Cancer
21.1 (2022): 1-17

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21.1 (2022): 1-18

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39 (2021): 1-16

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30.8 (2022): 1124-1138

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31.5 (2023): 766-780

Cell Host Microbe
31.3 (2023): 418-43

Cell Metabolism
34.2 (2022): 240-255

Ann Rheum Dis
82(4): 533-545 (2023)

Cell Mol Immunol
20, 264–276 (2023)

Adv Funct Mater
33.35 (2023): 2214998

Description Chemical Properties Product Documents

Product Documents

Quality Control & SDS

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Purity: >98.00%

IRL 1620 is a peptide endothelin type B (ET_B) receptor agonist.¹ It selectively binds to ET_B receptors (K_i = 16 pM) over ET_A receptors (IC₅₀ = 1.9 µM) and induces contraction of isolated guinea pig trachea when used at concentrations ranging from 0.01 to 1 µM. IRL 1620 (1 nmol/kg) reduces mean arterial pressure (MAP) in normotensive rats and spontaneously hypertensive rats (SHRs) and diminishes the transient depressor response in SHRs.² It reduces infarct volume and improves motor and neurological function in a rat model of cerebral ischemia.³ IRL 1620 also improves spatial memory deficits induced by amyloid-β (Aβ) in a rat model of Alzheimer’s disease.

1.Takai, M., Umemura, I., Yamasaki, K., et al.A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptorBiochem. Biophys. Res. Commun.184(2)953-959(1992) 2.James, A.F., Urade, Y., Webb, R.L., et al.IRL 1620, succinyl-[Glu9,Ala11,15]-endothelin-1(8-21), a highly specific agonist of the ETB receptorCardiovasc. Drug Rev.11(3)253-270(1993) 3.Gulati, A., Hornick, M.G., Briyal, S., et al.A novel neuroregenerative approach using ETB receptor agonist, IRL-1620, to treat CNS disordersPhysiol. Res.67(Suppl 1)S95-S113(2018)

Cas No.	N/A	SDF	Download SDF
Synonyms	PMZ-1620, SPI 1620, Suc-Glu9, Ala11,15-ET-1(8-21)
Canonical SMILES	OC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](C)NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](C(C)C)NC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC(CCC(O)=O)=O)=O)=O)=O)=O)=O)CC(C=C2)=CC=C2O)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O.OC(C(F)(F)F)=O
Formula	C86H117N17O27 • XCF3COOH	M.Wt	1820.9
Solubility	Water: soluble	Storage	-20°C
General tips	Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition	Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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		1 mg	5 mg	10 mg
	1 mM	0.5492 mL	2.7459 mL	5.4918 mL
	5 mM	0.1098 mL	0.5492 mL	1.0984 mL
	10 mM	0.0549 mL	0.2746 mL	0.5492 mL

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Average Rating: 5 ★★★★★ (Based on Reviews and 24 reference(s) in Google Scholar.)

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IRL 1620 (trifluoroacetate salt) (Synonyms: PMZ-1620, SPI 1620, Suc-Glu9, Ala11,15-ET-1(8-21))

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