Isoprinosine (Synonyms: Inosine pranobex, NP 113, NPT 10381) |
| Catalog No.GC18042 |
Isoprinosine is a potent, broad-spectrum antiviral compound for HIV infection.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 36703-88-5
Sample solution is provided at 25 µL, 10mM.
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Isoprinosine is a complex of acetaminobenzoic acid, dimethylaminoisopropanol, and inosine in a 3:3:1 ratio with immunomodulatory effects.
Immunotherapy is the treatment of disease by inducing, enhancing, or suppressing an immune response. Immunomodulatory regimens usually have fewer side effects than existing drugs, such as less potential for creating resistance when treating microbial disease.
In vitro: Previous study found that increasing concentrations of Isoprinosine (50-400 μg/mL) could produce progressively growing inhibitory effect on HHV-1 replication. The combination of 1000 IU/mL IFN-α and Isoprinosine could result in enhanced anti-HHV activity [1].
In vivo: Previous study demonstrated the positive effect of Isoprinosine treatment on persistent infection of Balb/c mice with murine gammaherpesvirus 68. Increased number of leukocytes, increased percentage of neutrophils, elevated levels of virus-neutralizing antibodies, reduced number of atypical lymphocytes and reduced virus titers were detected in the examined organs after a 14-day treatment. The positive effect of Isoprinosine therapy vanished after 120-150 days [2].
Clinical trial: A previous clinical study evaluating the safety of Isoprinosine for the treatment of patients with acute respiratory viral infections confirmed the efficacy of Isoprinosine versus placebo in healthy non-obese subjects less than 50 years of age with clinically diagnosed influenza-like illnesses [3].
References:
[1] Majewska A, Lasek W, Janyst M, Mynarczyk G. IN VITRO INfIBITION OF HHV-1 REPLICATION BY INOSINE PRANOBEX AND INTERFERON-α. Acta Pol Pharm. 2016 May-Jun;73(3):637-44.
[2] Janíková O, Anicová L, Briestenská K, Mistríková J. The effect of Isoprinosine treatment on persistent infection of Balb/c mice infected with murine gammaherpesvirus 68. Acta Virol. 2017;61(1):32-38. doi: 10.4149/av_2017_01_32.
[3] Beran J, alapová E, pajdel M; Isoprinosine Study (EWO ISO-2014/1) Team. Inosine pranobex is safe and effective for the treatment of subjects with confirmed acute respiratory viral infections: analysis and subgroup analysis from a Phase 4, randomised, placebo-controlled, double-blind study. BMC Infect Dis. 2016 Nov 7;16(1):648.
| Cas No. | 36703-88-5 | SDF | |
| Synonyms | Inosine pranobex, NP 113, NPT 10381 | ||
| Chemical Name | 1-(dimethylamino)-2-propanol 4-(acetylamino)benzoate inosine | ||
| Canonical SMILES | OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2NC=NC3=O)O1.OC(C4=CC=C(NC(C)=O)C=C4)=O.CC(O)CN(C)C.OC(C5=CC=C(NC(C)=O)C=C5)=O.CC(O)CN(C)C.OC(C6=CC=C(NC(C)=O)C=C6)=O.CC(O)CN(C)C | ||
| Formula | C10H12N4O5 • 3C9H9NO3 • 3C5H13NO | M.Wt | 1115.2 |
| Solubility | ≤14mg/ml in DMSO;2mg/ml in dimethyl formamide | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 0.8967 mL | 4.4835 mL | 8.967 mL |
| 5 mM | 0.1793 mL | 0.8967 mL | 1.7934 mL |
| 10 mM | 0.0897 mL | 0.4484 mL | 0.8967 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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