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IWP-O1 Catalog No.GC34628

Size Price Stock Qty
10mM*1mL in DMSO
$123.00
In stock
5mg
$111.00
In stock
10mg
$195.00
In stock
25mg
$417.00
In stock
50mg
$751.00
In stock
100mg
$1,344.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 2074607-48-8 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C(CN1N=NC(C2=CC=NC=C2)=C1C3=CC=CC=C3)NC4=NC=C(C5=CC=CC=C5)C=C4
Formula C26H20N6O M.Wt 432.48
Solubility DMSO : 125 mg/mL (289.03 mM);H2O : < 0.1 mg/mL (insoluble) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells, suppressing the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. IWP-O1 functions by preventing the secretion of Wnt proteins[1]. EC50: 80 pM (Porcn)[1].

[1]. You L, et al. Development of a triazole class of highly potent Porcn inhibitors. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895.