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1,1'-(Azodicarbonyl)dipiperidine (Synonyms: ADDP, NSC 356027)

カタログ番号GC46365

ミツノブ試薬

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1,1'-(Azodicarbonyl)dipiperidine 化学構造

Cas No.: 10465-81-3

サイズ 価格 在庫数 個数
1 g
$43.00
在庫あり
5 g
$108.00
在庫あり
10 g
$194.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

1,1'-(アゾジカルボニル)ジピペリジン(ADDP)は、アルコールと酸性化合物の縮合反応において一般的に使用されるミツノブ反応で用いられる試薬です。1,2 また、抗糖尿病活性を持つGタンパク質共役受容体120(GPR120)アゴニストやペルオキシソーム増殖因子活性化受容体α(PPARα)、PPARγ、およびPPARδトリプルアゴニストの合成においても使用されています。3,4

1.角田智、山宮康彦、伊藤茂。1,1'-(アゾジカルボニル)ジピペリジン-トリブチルホスフィン:三ツ野部反応のための新しい試薬系。テトラヘドロンレター34(10)1639-1642(1993年)。 2.広瀬大介、ガズヴォダ・マテイ、コシュムリ・ヨストら。2-アリールアゾカルボキシレートおよび2-アリールアゾカルボキサミドを Mitsunobu 試薬として系統的に評価する。J. Org. Chem.83(8)4712-4729(2018年)。 3.張学明、蔡超群、ウィンターズ・マイクら。GPR120 アゴニストとしての新規な一連の異種環式フェニルプロパン酸の設計合成および SAR 解析。Bioorg. Med. Chem.Lett27(15)3272-3278(2017) 4.Mogensen, J.P., Jeppesen, L., Bury, P.S., et al.Design and synthesis of novel PPARα/γ/δ triple activators using a known PPARα/γ dual activator as structural templateBioorg.Med.Chem.Lett.13(2)257-260(2003)

Chemical Properties

Cas No. 10465-81-3 SDF
同義語 ADDP, NSC 356027
Canonical SMILES O=C(/N=N/C(N1CCCCC1)=O)N2CCCCC2
Formula C12H20N4O2 M.Wt 252.3
溶解度 DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml,Ethanol: 1 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.9635 mL 19.8177 mL 39.6354 mL
5 mM 0.7927 mL 3.9635 mL 7.9271 mL
10 mM 0.3964 mL 1.9818 mL 3.9635 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

レビュー

Review for 1,1'-(Azodicarbonyl)dipiperidine

Average Rating: 5 ★★★★★ (Based on Reviews and 16 reference(s) in Google Scholar.)

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