1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt |
| カタログ番号GC68485 |
1,2-ジオレオイル-sn-グリセロ-3-リン酸 ナトリウム塩(1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt)(18:1 PA; DOPA)は陰イオン性の脂質であり、リポソーム、ミセルと人工膜の製造に使われることができる。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 108392-02-5
Sample solution is provided at 25 µL, 10mM.
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1,2-ジオレオイル-sn-グリセロ-3-リン酸 ナトリウム塩(1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt)(18:1 PA; DOPA)は陰イオン性の脂質であり、リポソーム、ミセルと人工膜の製造に使われることができる[1]。1,2-ジオレオイル-sn-グリセロ-3-リン酸はリン酸脂質で、sn-１とsn-2の位置に挿入されている長鎖脂肪酸オレイン酸を含めている[2]。1,2-ジオレオイル-sn-グリセロ-3-リン酸は、殆どの組織と細胞における主なホスファチジン酸（PA）種の一つである[3]。1,2-ジオレオイル-sn-グリセロ-3-リン酸 ナトリウム塩はZol-Ca複合ナノ粒子製剤の製造に使われことができ、マウス腫瘍モデルにおけるZolの輸送を増強させ、分化を促進させる[4]。カルシウムリン酸(CaP)コーディングDOPAリポソームは強い生物膜の染色能力を持っている[5]。
References:
[1] Siepi E. Mechanism of amphoteric liposomes & application for siRNA delivery[D]. Halle (Saale), Martin-Luther-Universität Halle-Wittenberg, Diss., 2010, 2010.
[2] Rouet‐Mayer M A, Valentova O, Simond‐Côte E, et al. Critical analysis of phospholipid hydrolyzing activities in ripening tomato fruits. Study by spectrofluorimetry and high‐performance liquid chromatography[J]. Lipids, 1995, 30(8): 739-746.
[3] Hoshino F, Sakane F. Polyunsaturated fatty acid-containing phosphatidic acids selectively interact with L-lactate dehydrogenase A and induce its secondary structural change and inactivation[J]. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2020, 1865(10): 158768.
[4] Li X, Naguib Y W, Valdes S, et al. Reverse Microemulsion-Based Synthesis of (Bis) phosphonate–Metal Materials with Controllable Physical Properties: An Example Using Zoledronic Acid–Calcium Complexes[J]. ACS applied materials & interfaces, 2017, 9(16): 14478-14489.
[5] Berti I R, Dell’Arciprete M L, Dittler M L, et al. Delivery of fluorophores by calcium phosphate-coated nanoliposomes and interaction with Staphylococcus aureus biofilms[J]. Colloids and Surfaces B: Biointerfaces, 2016, 142: 214-222.
| Cas No. | 108392-02-5 | SDF | |
| Formula | C39H72NaO8P | M.Wt | 722.95 |
| 溶解度 | Methanol : 10 mg/mL (13.83 mM; Need ultrasonic) | Storage | Store at -20°C, away from moisture and light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.3832 mL | 6.9161 mL | 13.8322 mL |
| 5 mM | 0.2766 mL | 1.3832 mL | 2.7664 mL |
| 10 mM | 0.1383 mL | 0.6916 mL | 1.3832 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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